Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 19/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 19/20 | 0.39 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31068287 | 1.00 | DDB1 (0.39) | DDB1CRBNPDCD1LG2CD274 | |
| SCHEMBL29348651 | 0.84 | CRBN (0.41) | DDB1CRBNPDCD1LG2CD274 | |
| SCHEMBL31068203 | 0.84 | CRBN (0.41) | DDB1CRBNPDCD1LG2CD274 | |
| SCHEMBL29348400 | 0.83 | CRBN (0.46) | DDB1CRBNCD274 | |
| SCHEMBL29348592 | 0.83 | DDB1 (0.41) | DDB1CRBNPDCD1LG2CD274 | |
| SCHEMBL29348660 | 0.83 | DDB1 (0.39) | DDB1CRBNPDCD1LG2CD274 | |
| SCHEMBL29348589 | 0.82 | DDB1 (0.40) | DDB1CRBN | |
| SCHEMBL29348436 | 0.82 | CRBN (0.44) | DDB1CRBN | |
| SCHEMBL29348671 | 0.82 | CRBN (0.39) | DDB1CRBNPDCD1LG2CD274 | |
| SCHEMBL29348391 | 0.82 | DDB1 (0.39) | DDB1CRBNPDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250205219-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS AG (CH) | 2025-06-26 | — | — | US | disclosed |
| US-12257247-B2 | Targeted degradation of VAV1 | MONTE ROSA THERAPEUTICS AG (CH) | 2025-03-25 | — | — | US | disclosed |
| US-20240285604-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS AG (CH) | 2024-08-29 | — | — | US | disclosed |
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240285604-A1 | TARGETED DEGRADATION OF VAV1 | VAV1, KRAS, CBL | DDB1 1125/4885CRBN 144/4885PDCD1LG2 552/4885 |
| US-12257247-B2 | Targeted degradation of VAV1 | VAV1, KRAS, CBL | DDB1 1125/4885CRBN 144/4885PDCD1LG2 552/4885 |
| US-20250205219-A1 | TARGETED DEGRADATION OF VAV1 | VAV1, KRAS, CBL | DDB1 1125/4885CRBN 144/4885PDCD1LG2 552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.