Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lapatinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 17/20 | 1.00 |
| ▸ | ERBB2 known ✓ | P04626 | 13/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | PIK3C2B | O00750 | 1/20 | 1.00 |
| ▸ | MAP2K7 | O14733 | 1/20 | 1.00 |
| ▸ | RIPK2 | O43353 | 1/20 | 1.00 |
| ▸ | PIK3C2G | O75747 | 1/20 | 1.00 |
| ▸ | STK10 | O94804 | 1/20 | 1.00 |
| ▸ | ABL1 | P00519 | 1/20 | 1.00 |
| ▸ | INSR | P06213 | 1/20 | 1.00 |
| ▸ | RET | P07949 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 1/20 | 1.00 |
| ▸ | SRC | P12931 | 1/20 | 1.00 |
| ▸ | CYP3A5 | P20815 | 1/20 | 1.00 |
| ▸ | ERBB3 | P21860 | 1/20 | 1.00 |
| ▸ | CDK2 | P24941 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lapatinib SCHEMBL8100 | 1.00 | EGFR (1.00) | EGFRERBB2ABCB11MEN1PIK3C2B | |
| Lapatinib SCHEMBL16766960 | 1.00 | EGFR (1.00) | EGFRERBB2ABCB11MEN1PIK3C2B | |
| Lapatinib SCHEMBL29464189 | 1.00 | EGFR (1.00) | EGFRERBB2ABCB11MEN1PIK3C2B | |
| Lapatinib SCHEMBL3232460 | 0.99 | EGFR (0.99) | EGFRERBB2ABCB11MEN1PIK3C2B | |
| Lapatinib SCHEMBL3232064 | 0.99 | EGFR (0.99) | EGFRERBB2ABCB11MEN1PIK3C2B | |
| Lapatinib SCHEMBL4924110 | 0.99 | EGFR (0.99) | EGFRERBB2ABCB11MEN1PIK3C2B | |
| Lapatinib SCHEMBL574229 | 0.99 | EGFR (0.99) | EGFRERBB2ABCB11MEN1PIK3C2B | |
| Lapatinib SCHEMBL3637153 | 0.99 | EGFR (0.99) | EGFRERBB2ABCB11MEN1PIK3C2B | |
| Lapatinib SCHEMBL18691854 | 0.99 | EGFR (0.97) | EGFRERBB2ABCB11MEN1PIK3C2B | |
| Lapatinib SCHEMBL2505835 | 0.99 | EGFR (0.97) | EGFRERBB2ABCB11MEN1PIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 563 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260051533-A1 | ANODE SUPPORTED SOLID-STATE ELECTROLYTE SEPARATORS | GM GLOBAL TECH OPERATIONS LLC (US) | 2026-02-19 | — | — | US | claimed |
| US-12456755-B2 | Electrolyte for lithium secondary battery, and lithium secondary battery comprising same | LG ENERGY SOLUTION, LTD. (KR) | 2025-10-28 | — | — | US | claimed |
| EP-4120419-B1 | ELECTROLYTE FOR LITHIUM SECONDARY BATTERY, AND LITHIUM SECONDARY BATTERY COMPRISING SAME | LG ENERGY SOLUTION LTD (KR) | 2025-07-23 | — | — | EP | claimed |
| WO-2025110454-A1 | METHOD FOR RECYCLING WASTE SECONDARY BATTERY ELECTRODE MATERIAL | 한국에너지기술연구원 | 2025-05-30 | — | — | WO | claimed |
| CN-119315092-A | Modified intermediate layer containing sulfonic acid, three-dimensional polymer frame and crosslinked polymer for lithium battery | 中国科学院上海硅酸盐研究所 | 2025-01-14 | — | — | CN | claimed |
| US-20240413384-A1 | Solid-Liquid Composite Electrolyte Including Sulfide-based Solid Electrolyte and High-kosmotropicity Salt-containing Liquid Electrolyte, and Semi-solid-state Rechargeable Batteries | UIF (UNIVERSITY INDUSTRY FOUNDATION), YONSEI UNIVERSITY (KR) | 2024-12-12 | — | — | US | claimed |
| US-20240413382-A1 | Solid-liquid Composite Electrolyte including Sulfide-based Solid Electrolyte and Liquid Electrolyte, and Semi-solid-state Rechargeable Batteries | UIF (UNIVERSITY INDUSTRY FOUNDATION), YONSEI UNIVERSITY (KR) | 2024-12-12 | — | — | US | claimed |
| US-20240413383-A1 | Solid-Liquid Composite Electrolyte Including Sulfide-based Solid Electrolyte and High-concentration Liquid Electrolyte, and Semi-solid-state Rechargeable Batteries | UI (UNIVERSITY INDUSTRY FOUNDATION), YONSEI UNIVERSITY (KR) | 2024-12-12 | — | — | US | claimed |
| CN-119009132-A | High-energy lithium ion battery electrolyte | 山东海容电源材料有限公司 | 2024-11-22 | — | — | CN | claimed |
| US-20240322244-A1 | LOCALIZED HIGH CONCENTRATION ELECTROLYTE AND LITHIUM-ION BATTERY COMPRISING THE SAME | SILA NANOTECHNOLOGIES, INC. | 2024-09-26 | — | — | US | claimed |
| WO-2023287178-A1 | NON-AQUEOUS ELECTROLYTE SOLUTION FOR LITHIUM SECONDARY BATTERY, AND LITHIUM SECONDARY BATTERY COMPRISING SAME | 주식회사 엘지에너지솔루션 | 2023-01-19 | — | — | WO | claimed |
| EP-4120419-A1 | ELECTROLYTE FOR LITHIUM SECONDARY BATTERY, AND LITHIUM SECONDARY BATTERY COMPRISING SAME | LG Energy Solution, Ltd. (KR) | 2023-01-18 | — | — | EP | claimed |
| CN-115275355-A | Mixed ether-based electrolyte for low-temperature lithium battery | 中国科学院金属研究所 | 2022-11-01 | — | — | CN | claimed |
| CN-114824468-A | Multifunctional lithium battery additive containing fluorine and boron substances and application thereof | 中国科学院物理研究所 | 2022-07-29 | — | — | CN | claimed |
| CN-113140794-B | Electrolyte film forming additive and lithium ion battery electrolyte containing same | 山东海容电源材料有限公司 | 2022-07-12 | — | — | CN | claimed |
| CN-113140793-B | High-voltage lithium ion electrolyte and application thereof | 山东海容电源材料有限公司 | 2022-07-12 | — | — | CN | claimed |
| CN-112271328-B | Lithium ion battery electrolyte and lithium ion battery | 东莞市创明电池技术有限公司 | 2022-06-03 | — | — | CN | claimed |
| WO-2022092831-A1 | ELECTROLYTE FOR LITHIUM SECONDARY BATTERY, AND LITHIUM SECONDARY BATTERY COMPRISING SAME | 주식회사 엘지에너지솔루션 | 2022-05-05 | — | — | WO | claimed |
| US-20220109146-A1 | PERFORMANCE IMPROVEMENTS OF SILICON-DOMINANT ANODE CONTAINING LITHIUM ION BATTERIES THROUGH THE USE OF FLUORINATED ESTER/CARBONATES/AROMATIC COMPOUNDS AND MULTIPLE ADDITIVE COMBINATION CONTAINING ELECTROLYTES | ENEVATE CORPORATION | 2022-04-07 | — | — | US | claimed |
| WO-2022072417-A1 | PERFORMANCE IMPROVEMENTS OF SILICON-DOMINANT ANODE CONTAINING LITHIUM ION BATTERIES THROUGH THE USE OF FLUORINATED ESTERS/CARBONATES/AROMATIC COMPOUNDS AND MULTIPLE ADDITIVE COMBINATION CONTAINING ELECTROLYTES | ENEVATE CORPORATION (US) | 2022-04-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260051533-A1 | ANODE SUPPORTED SOLID-STATE ELECTROLYTE SEPARATORS | XPO4, XPA, CACNA2D4 | EGFR 1652/4885ERBB2 1015/4885ABCB11 2333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.