Melittin

Melittin

SCHEMBL29351537

CC[C@H](C)[C@H](NC(=O)CN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ CXCR4 P61073 10/20 0.66
▸ RXFP1 Q9HBX9 1/20 0.64
▸ NPY1R P25929 1/20 0.63
▸ NPY2R P49146 1/20 0.63
▸ NPY4R P50391 1/20 0.63
▸ NPY5R Q15761 1/20 0.63
▸ IL23R Q5VWK5 1/20 0.62
▸ GLP1R P43220 2/20 0.62
▸ KEAP1 Q14145 1/20 0.59
▸ CALCA P06881 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Melittin SCHEMBL19458851 1.00 CXCR4 (0.66) CXCR4RXFP1NPY1RNPY2RNPY4R
SCHEMBL30978816 0.98 CXCR4 (0.70) CXCR4RXFP1NPY1RNPY2RNPY4R
SCHEMBL29973066 0.97 NPY1R (0.66) CXCR4RXFP1NPY1RNPY2RNPY4R
SCHEMBL30709702 0.97 NPY1R (0.66) CXCR4RXFP1NPY1RNPY2RNPY4R
SCHEMBL29993191 0.97 IL23R (0.66) CXCR4RXFP1NPY1RNPY2RNPY4R
SCHEMBL30456690 0.94 NPY2R (0.68) CXCR4NPY1RNPY2RNPY4RNPY5R
SCHEMBL29385720 0.94 CXCR4 (0.61) CXCR4RXFP1NPY1RNPY2RNPY4R
SCHEMBL29993338 0.94 NPY1R (0.67) CXCR4RXFP1NPY1RNPY2RNPY4R
SCHEMBL29989757 0.93 NPY2R (0.67) CXCR4RXFP1NPY1RNPY2RNPY4R
SCHEMBL30456977 0.92 NPY1R (0.66) CXCR4NPY1RNPY2RNPY4RNPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3609 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144897-A1 Methods of Targeting Mutant Cells PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2026-05-28 — — US claimed
CN-122075438-A Synergistic anticancer application of redox responsive coacervate delivery chrysin and 3-methyladenine — 2026-05-26 — — CN claimed
CN-122031677-A Leptin receptor agonist antibodies for the treatment of metabolic dysfunction or hypoleptinemia 瑞泽恩制药公司 2026-05-15 — — CN claimed
CN-122031654-A Targeting delivery nano-carrier antibacterial protein, preparation method and application thereof 海泰达生物科技(广州)有限公司 2026-05-15 — — CN claimed
CN-122031655-A Melittin nano-composite temperature-sensitive hydrogel and application thereof in preventing postoperative recurrence of breast cancer 江苏省人民医院宿迁医院(宿迁市第一人民医院) 2026-05-15 — — CN claimed
US-20260102500-A1 PKC INHIBITORS FOR THE TREATMENT OF SEPTIC CHOLESTASIS WITH POLYMETHINE DYE TARGETING SMARTDYELIVERY GMBH (DE) 2026-04-16 — — US claimed
EP-4710943-A2 TRANSFECTION COMPLEXES AND METHODS OF USING THE SAME Molecular Transfer, Inc. (US) 2026-03-18 — — EP claimed
US-12560607-B2 Recombinant viruses, insect cells and their uses in viral detection and vaccination ACADEMIA SINICA (TW) 2026-02-24 — — US claimed
US-20260022390-A1 RECOMBINANT EXPRESSION VECTOR FOR MELITTIN SECRETION AND ATTENUATED SALMONELLA STRAIN TRANSFORMED THEREWITH THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC) (KR) 2026-01-22 — — US claimed
EP-4677075-A2 TARGETING CELLS IN STRESSED GROWING CONDITIONS SNIPR Biome ApS (DK) 2026-01-14 — — EP claimed
US-20220090141-A1 TRANSFECTION COMPLEXES AND METHODS OF USING THE SAME MOLECULAR TRANSFER, INC. 2022-03-24 — — US claimed
CN-109045281-B Composition containing refined melittin, and its preparation method and pharmaceutical use 祝国光 2022-03-22 — — CN claimed
CN-108164584-B VAP polypeptide and application thereof in preparation of targeted tumor diagnosis and treatment medicines 复旦大学 2022-03-18 — — CN claimed
CN-114190561-A Microencapsulated royal jelly enzymolysis polypeptide, preparation method thereof and solid powder containing microencapsulated royal jelly enzymolysis polypeptide 北京中蜜科技发展有限公司 2022-03-18 — — CN claimed
CN-112190716-B Dynamic drug-loaded compound based on DNA tetrahedron 四川大学 2022-03-11 — — CN claimed
CN-114146013-A Mouthwash for killing helicobacter pylori, preparation method and portable packaging bag 北京洗得宝消毒制品有限公司 2022-03-08 — — CN claimed
CN-114129737-A Compositions and methods relating to particle removal 纳米提克斯有限责任公司 2022-03-04 — — CN claimed
CN-114129553-A anti-HPV bioprotein gel containing garlic extract 安徽德莱康生物医疗科技有限公司 2022-03-04 — — CN claimed
CN-114028540-A Composition with analgesic effect, microneedle patch and preparation method and application of microneedle patch 海南鑫开源医药科技有限公司 2022-02-11 — — CN claimed
US-20220023244-A1 FORMULATION FOR TOPICAL TREATMENT OF ACUTE WOUNDS KING ABDULAZIZ UNIVERSITY (SA) 2022-01-27 — — US claimed
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