Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | NPC1 | O15118 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | IGF1R | P08069 | 6/20 | 0.65 |
| ▸ | SYK | P43405 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116426 | 0.83 | IGF1R (0.74) | MEN1NPC1LMNAMAPTMAPK1 | |
| SCHEMBL4621303 | 0.80 | NPC1 (0.87) | MEN1NPC1LMNAMAPTMAPK1 | |
| SCHEMBL6980742 | 0.79 | FAM20C (0.78) | MEN1NPC1LMNAMAPTMAPK1 | |
| SCHEMBL3301709 | 0.79 | MEN1 (0.69) | MEN1NPC1LMNAMAPTMAPK1 | |
| SCHEMBL1377802 | 0.79 | EGFR (1.00) | MEN1NPC1LMNAMAPTMAPK1 | |
| SCHEMBL31046394 | 0.78 | EGFR (0.92) | MEN1NPC1LMNAMAPTMAPK1 | |
| SCHEMBL30629802 | 0.77 | MEN1 (0.57) | MEN1NPC1LMNAMAPTMAPK1 | |
| SCHEMBL26113881 | 0.77 | MEN1 (0.57) | MEN1NPC1LMNAMAPTMAPK1 | |
| SCHEMBL13844955 | 0.76 | MAPK1 (0.79) | MEN1NPC1LMNAMAPTMAPK1 | |
| SCHEMBL14650292 | 0.76 | IGF1R (0.63) | MEN1NPC1LMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12377194-B2 | JAB1 inhibitory compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2025-08-05 | — | — | US | disclosed |
| US-20220023506-A1 | JAB1 Inhibitory Compositions for Ossification and Methods Related Thereto | EMORY UNIVERSITY | 2022-01-27 | — | — | US | disclosed |