SCHEMBL29360419

SCHEMBL29360419

COC(=O)C1CC(C#N)(c2ccc(OC(F)F)c(OCC3CC3)c2)CCC1=O

nearest known ligand 0.49

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 15/20 0.49
PDE4A P27815 11/20 0.49
PDE4C Q08493 11/20 0.49
PDE4D Q08499 11/20 0.49
PDE1C Q14123 5/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL109922 1.00 PDE4B (0.49) PDE4BPDE4APDE4CPDE4DPDE1C
SCHEMBL7418879 0.91 PDE4B (0.51) PDE4BPDE4APDE4CPDE4DPDE1C
SCHEMBL7416606 0.90 PDE4B (0.60) PDE4BPDE4APDE4CPDE4D
SCHEMBL7415505 0.90 PDE4A (0.45) PDE4BPDE4APDE4CPDE4D
SCHEMBL7467100 0.90 PDE4B (0.49) PDE4BPDE4APDE4CPDE4DPDE1C
SCHEMBL7466462 0.87 PDE4A (0.51) PDE4BPDE4APDE4CPDE4D
SCHEMBL6816264 0.86 PDE4A (0.59) PDE4BPDE4APDE4CPDE4D
SCHEMBL29008297 0.86 PDE4B (0.48) PDE4BPDE4APDE4CPDE4DPDE1C
SCHEMBL931420 0.84 PDE4B (0.53) PDE4BPDE4APDE4CPDE4DPDE1C
SCHEMBL5799817 0.84 PDE4B (0.55) PDE4BPDE4APDE4CPDE4DPDE1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115916305-B Multi-carrier medicament dispenser 陆品公司 2025-03-21 CN disclosed
EP-3436446-B1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2023-06-07 EP disclosed
EP-4185997-A1 DOSE COUNTER ASSEMBLIES FOR MEDICAMENT DISPENSERS Lupin Inc. (US) 2023-05-31 EP disclosed
CN-116194114-A Cathepsin inhibitors for preventing or treating viral infections 葛兰素史密斯克莱知识产权发展有限公司 2023-05-30 CN disclosed
CN-115916305-A Multi-carrier medicament dispenser 陆品公司 2023-04-04 CN disclosed
EP-4126139-A1 MULTI-CARRIER MEDICAMENT DISPENSERS Lupin Inc. (US) 2023-02-08 EP disclosed
EP-4125919-A1 CATHEPSIN INHIBITORS FOR PREVENTING OR TREATING VIRAL INFECTIONS GlaxoSmithKline Intellectual Property Development Limited (GB) 2023-02-08 EP disclosed
CN-110840847-B Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases 沃泰克斯药物股份有限公司 2022-07-29 CN disclosed
WO-2022020506-A1 DOSE COUNTER ASSEMBLIES FOR MEDICAMENT DISPENSERS Lupin Inc. (US) 2022-01-27 WO disclosed