Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.30 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25212070 | 1.00 | CYP1A2 (0.33) | CYP1A2CYP11B1CYP11B2CES1CRBN | |
| SCHEMBL24191776 | 0.85 | GRIA1 (0.36) | CES1PDE3BPDE3AHTTSMN1; SMN2 | |
| SCHEMBL20417278 | 0.83 | CRBN (0.40) | CYP1A2CRBNPDE3BPDE3ADDB1 | |
| SCHEMBL13410700 | 0.74 | UHRF1 (0.33) | HTTTP53NPC1MAPTRAB9A | |
| SCHEMBL25028942 | 0.71 | UHRF1 (0.41) | CYP1A2HTTTP53NPC1MAPT | |
| SCHEMBL18786660 | 0.70 | TYMS (0.36) | TYMSHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL25816050 | 0.70 | CRBN (0.38) | CRBNPDE3BPDE3ADDB1TYMS | |
| SCHEMBL14494399 | 0.69 | PDE3A (0.36) | CYP1A2CYP11B1CYP11B2CRBNPDE3B | |
| SCHEMBL12559731 | 0.68 | CES1 (0.34) | CYP1A2CYP11B1CYP11B2CES1CRBN | |
| SCHEMBL20938817 | 0.68 | TP53 (0.37) | CYP1A2CYP11B1CYP11B2CES1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4182320-A1 | INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | Nido Biosciences, Inc. (US) | 2023-05-24 | — | — | EP | disclosed |
| WO-2022020342-A1 | INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | NIDO BIOSCIENCES, INC. (US) | 2022-01-27 | — | — | WO | disclosed |