SCHEMBL29365791

SCHEMBL29365791

COc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KDR P35968 16/20 1.00
FLT1 P17948 15/20 1.00
FGFR1 P11362 10/20 1.00
FLT4 P35916 6/20 1.00
EPHB2 P29323 1/20 1.00
EGFR P00533 7/20 0.84
SRC P12931 1/20 0.78
RET P07949 2/20 0.76
KIF5B P33176 2/20 0.76
FGFR2 P21802 1/20 0.71
FGFR4 P22455 1/20 0.71
FGFR3 P22607 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3012896 1.00 KDR (1.00) KDRFLT1FGFR1FLT4EPHB2
Hydrochloric Acid SCHEMBL7867640 0.99 KDR (0.98) KDRFLT1FGFR1FLT4EPHB2
Hydrochloric Acid SCHEMBL30078372 0.99 KDR (0.98) KDRFLT1FGFR1FLT4EPHB2
SCHEMBL1468310 0.92 FLT1 (0.85) KDRFLT1FGFR1FLT4EPHB2
SCHEMBL7867151 0.92 FLT1 (1.00) KDRFLT1FGFR1FLT4EPHB2
SCHEMBL21557447 0.91 KDR (0.83) KDRFLT1FGFR1FLT4EPHB2
SCHEMBL1467058 0.91 KDR (0.83) KDRFLT1FGFR1FLT4EPHB2
SCHEMBL7864752 0.91 FLT1 (0.83) KDRFLT1FGFR1FLT4EPHB2
SCHEMBL7867708 0.91 FLT1 (0.83) KDRFLT1FGFR1FLT4EPHB2
Hydrochloric Acid SCHEMBL7859481 0.91 FLT1 (0.98) KDRFLT1FGFR1FLT4EPHB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250346635-A1 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 (VEGFR-1) INHIBITORS FOR PROMOTING MYELINATION AND NEUROPROTECTION ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÉRE) (FR) 2025-11-13 US claimed
EP-4547252-A1 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 (VEGFR-1) INHIBITORS FOR PROMOTING MYELINATION AND NEUROPROTECTION ICM (Institut du Cerveau et de la Moelle Épinière) (FR) 2025-05-07 EP claimed
EP-4539924-A1 COMPOSITIONS, SYSTEMS, AND METHODS FOR TREATING CANCER USING TUMOR TREATING FIELDS AND VEGF INHIBITORS Novocure GmbH (CH) 2025-04-23 EP claimed
CN-119451723-A Compositions, systems, and methods for treating cancer using a tumor treating electric field and a VEGF inhibitor 诺沃库勒有限责任公司 2025-02-14 CN claimed
US-20240336977-A1 MICRORNA-REGULATED BIOMARKERS AND DRUG TARGETS FOR IMPROVING DIAGNOSIS AND TREATMENT OF LUNG OR BREAST CANCER West Virginia University Board of Governors on behalf of West Virginia University (US) 2024-10-10 US claimed
US-20240200147-A1 Non-Small Cell Lung Cancer Diagnosis and Treatment THE WEST VIRGINIA UNIVERSITY BOARD OF GOVERNORS ON BEHALF OF WEST VIRGINIA UNIVERSITY 2024-06-20 US claimed
WO-2024003380-A1 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 (VEGFR-1) INHIBITORS FOR PROMOTING MYELINATION AND NEUROPROTECTION ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE) (FR) 2024-01-04 WO claimed
WO-2023248139-A1 COMPOSITIONS, SYSTEMS, AND METHODS FOR TREATING CANCER USING TUMOR TREATING FIELDS AND VEGF INHIBITORS NOVOCURE GMBH (CH) 2023-12-28 WO claimed
US-20230405316-A1 COMPOSITIONS, SYSTEMS, AND METHODS FOR TREATING CANCER USING TUMOR TREATING FIELDS AND VEGF INHIBITORS NOVOCURE GMBH (CH) 2023-12-21 US claimed
EP-3337477-B1 COMPOSITIONS COMPRISING PHOSPHOINOSITIDE 3-KINASE INHIBITORS AND A SECOND ANTIPROLIFERATIVE AGENT CONVALIFE SHANGHAI CO LTD (CN) 2023-02-01 EP claimed
EP-4739310-A1 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) INHIBITOR COMBINATIONS AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-05-13 EP disclosed
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 EP disclosed
US-20250346635-A1 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 (VEGFR-1) INHIBITORS FOR PROMOTING MYELINATION AND NEUROPROTECTION ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÉRE) (FR) 2025-11-13 US disclosed
EP-4615869-A1 COMBINATION THERAPY COMPRISING BISPECIFIC ANTIBODIES COMPRISING AN NRP1 BINDING DOMAIN Pinetree Therapeutics, Inc. (US) 2025-09-17 EP disclosed
US-20250283077-A1 ENHANCED HAMMERHEAD RIBOZYMES AND METHODS OF USE US GOV VETERANS AFFAIRS (US) 2025-09-11 US disclosed
WO-2022076938-A1 APPARATUS AND METHODS OF RETINAL INJECTION CLEARSIDE BIOMEDICAL, INC. (US) 2022-04-14 WO disclosed
US-11291669-B2 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent KARUS THERAPEUTICS LIMITED (GB) 2022-04-05 US disclosed
CN-114028568-A Method for preventing or treating side effects of tumor therapy 上海岸阔医药科技有限公司 2022-02-11 CN disclosed
US-11234955-B2 Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem cells including glioblastoma multiforme and medulloblastoma DEL MAR PHARMACEUTICALS (BC) LTD. (CA) 2022-02-01 US disclosed
CN-113975264-A Method for preventing or treating side effects of tumor therapy 上海岸阔医药科技有限公司 2022-01-28 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250346635-A1 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 (VEGFR-1) INHIBITORS FOR PROMOTING MYELINATION AND NEUROPROTECTION FLT1, KDR, FLT4 KDR 2/4885FLT1 1/4885FGFR1 50/4885
US-11291669-B2 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent MCL1, MYC, XIAP KDR 1380/4885FLT1 1971/4885FGFR1 2333/4885
US-11234955-B2 Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem cells including glioblastoma multiforme and medulloblastoma MGMT, MPG, HDAC7 KDR 2810/4885FLT1 2692/4885FGFR1 2862/4885
US-20240200147-A1 Non-Small Cell Lung Cancer Diagnosis and Treatment H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, PDCD1, PDCD10 KDR 4597/4885FLT1 2543/4885FGFR1 2507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.