SCHEMBL29367106

SCHEMBL29367106

Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDR P35968 20/20 0.67
BRAF P15056 12/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16904535 1.00 KDR (0.67) KDRBRAF
SCHEMBL29788830 0.86 KDR (0.60) KDRBRAF
SCHEMBL14976311 0.86 KDR (0.61) KDRBRAF
SCHEMBL16904546 0.86 KDR (0.60) KDRBRAF
SCHEMBL20040899 0.86 KDR (0.66) KDRBRAF
SCHEMBL30965184 0.86 KDR (0.61) KDRBRAF
SCHEMBL4323278 0.86 KDR (0.55) KDRBRAF
SCHEMBL27713139 0.86 KDR (0.64) KDRBRAF
SCHEMBL1136958 0.85 GCK (0.56) KDRBRAF
SCHEMBL30844471 0.85 GCK (0.56) KDRBRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117343046-A Novel 3-oxo-4-substituted aryl-3, 4-dihydropyrazine-2-carboxamide compound and application thereof 辽宁大学 2024-01-05 CN disclosed
CN-113999205-B Pyridine compound containing triazolone amide and imidazolone amide structures and application thereof 辽宁大学 2023-09-15 CN disclosed
CN-111440177-B Substituted pyrazolo [1,5-a ] pyrimidine compound and preparation method and application thereof 辽宁大学 2022-06-14 CN disclosed
CN-113999205-A Pyridine compound containing triazole ketoamide and imidazole amide structures and application thereof 辽宁大学 2022-02-01 CN disclosed