Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.97 |
| ▸ | HPGD | P15428 | 2/20 | 0.75 |
| ▸ | DRD4 | P21917 | 13/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | DRD2 | P14416 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.64 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.63 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12045417 | 1.00 | HTT (0.97) | HTTHPGDDRD4KDM4EALDH1A1 | |
| SCHEMBL31010306 | 0.98 | HTT (1.00) | HTTHPGDDRD4KDM4EALDH1A1 | |
| SCHEMBL22633621 | 0.98 | HTT (1.00) | HTTHPGDDRD4KDM4EALDH1A1 | |
| SCHEMBL15063202 | 0.98 | HTT (1.00) | HTTHPGDDRD4KDM4EALDH1A1 | |
| SCHEMBL5157052 | 0.93 | HTT (0.84) | HTTHPGDDRD4KDM4EALDH1A1 | |
| SCHEMBL3738083 | 0.91 | HTT (0.81) | HTTHPGDDRD4KDM4EALDH1A1 | |
| SCHEMBL9202923 | 0.88 | HTT (0.76) | HTTHPGDDRD4KDM4EALDH1A1 | |
| SCHEMBL22639783 | 0.88 | HTT (0.76) | HTTHPGDDRD4KDM4EALDH1A1 | |
| SCHEMBL18011118 | 0.88 | HTT (0.76) | HTTHPGDDRD4KDM4EALDH1A1 | |
| SCHEMBL13833225 | 0.87 | HTT (0.75) | HTTHPGDDRD4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976187-A1 | METHODS AND COMPOSITIONS FOR TREATING EPILEPSY | The Regents of the University of California (US) | 2022-04-06 | — | — | EP | disclosed |
| CN-114007692-A | Methods and compositions for treating epilepsy | 加利福尼亚大学董事会 | 2022-02-01 | — | — | CN | disclosed |