Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.67 |
| ▸ | CDK1 | P06493 | 19/20 | 0.67 |
| ▸ | CDK2 | P24941 | 19/20 | 0.67 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776257 | 1.00 | KDR (0.67) | KDRCDK1CDK2CA2CCNB1 | |
| SCHEMBL1776255 | 1.00 | KDR (0.67) | KDRCDK1CDK2CA2CCNB1 | |
| SCHEMBL1775402 | 0.94 | KDR (0.64) | KDRCDK1CDK2CA2CCNB1 | |
| SCHEMBL1775404 | 0.94 | KDR (0.64) | KDRCDK1CDK2CA2CCNB1 | |
| SCHEMBL2941712 | 0.94 | KDR (0.64) | KDRCDK1CDK2CA2CCNB1 | |
| SCHEMBL2934293 | 0.91 | KDR (0.69) | KDRCDK1CDK2CA2CCNB1 | |
| SCHEMBL1776403 | 0.91 | KDR (0.69) | KDRCDK1CDK2CA2CCNB1 | |
| SCHEMBL1776401 | 0.91 | KDR (0.69) | KDRCDK1CDK2CA2CCNB1 | |
| SCHEMBL1773742 | 0.90 | KDR (0.66) | KDRCDK1CDK2CA2CCNB1 | |
| SCHEMBL1773743 | 0.90 | KDR (0.66) | KDRCDK1CDK2CA2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029552-B1 | SULFIMIDES AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AG (DE) | 2010-09-22 | — | — | EP | disclosed |
| EP-2029552-A1 | SULFIMIDES AS PROTEIN KINASE INHIBITORS | Bayer Schering Pharma AG (DE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140957-A1 | SULFIMIDES AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-13 | — | — | WO | disclosed |