Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.54 |
| ▸ | BRD4 | O60885 | 3/20 | 0.54 |
| ▸ | JAK3 | P52333 | 7/20 | 0.51 |
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376235 | 1.00 | JAK2 (0.54) | JAK2BRD4JAK3JAK1PTK2 | |
| SCHEMBL29371785 | 0.90 | JAK2 (0.56) | JAK2BRD4JAK3JAK1PTK2 | |
| SCHEMBL18376242 | 0.90 | JAK2 (0.56) | JAK2BRD4JAK3JAK1PTK2 | |
| SCHEMBL18376225 | 0.87 | JAK2 (0.59) | JAK2BRD4JAK3JAK1PTK2 | |
| SCHEMBL29371281 | 0.86 | JAK2 (0.55) | JAK2BRD4JAK3JAK1PTK2 | |
| SCHEMBL18376725 | 0.86 | JAK2 (0.55) | JAK2BRD4JAK3JAK1PTK2 | |
| SCHEMBL29371867 | 0.86 | JAK2 (0.60) | JAK2BRD4JAK3JAK1PTK2 | |
| SCHEMBL29371805 | 0.86 | JAK2 (0.58) | JAK2BRD4JAK3JAK1PTK2 | |
| SCHEMBL18376589 | 0.86 | JAK2 (0.58) | JAK2BRD4JAK3JAK1PTK2 | |
| SCHEMBL18376722 | 0.86 | JAK2 (0.60) | JAK2BRD4JAK3JAK1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |