Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 6/20 | 0.61 |
| ▸ | BRD4 | O60885 | 2/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.56 |
| ▸ | JUN | P05412 | 4/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376727 | 1.00 | TTK (0.61) | TTKJAK2BRD4MAPK10JUN | |
| SCHEMBL18376233 | 0.94 | JAK2 (0.63) | TTKJAK2BRD4MAPK10JUN | |
| SCHEMBL18377031 | 0.92 | JAK2 (0.55) | TTKJAK2BRD4MAPK10JUN | |
| SCHEMBL18376225 | 0.89 | JAK2 (0.59) | TTKJAK2BRD4FGFR1KDR | |
| SCHEMBL18376589 | 0.89 | JAK2 (0.58) | TTKJAK2BRD4FGFR1KDR | |
| SCHEMBL29371805 | 0.89 | JAK2 (0.58) | TTKJAK2BRD4FGFR1KDR | |
| SCHEMBL29371867 | 0.89 | JAK2 (0.60) | JAK2BRD4FGFR1KDRCCNT1 | |
| SCHEMBL18376722 | 0.89 | JAK2 (0.60) | JAK2BRD4FGFR1KDRCCNT1 | |
| SCHEMBL30859695 | 0.88 | TTK (0.65) | TTKJAK2MAPK10JUNMAPK8 | |
| SCHEMBL18376252 | 0.88 | TTK (0.65) | TTKJAK2MAPK10JUNMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |