Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 2/20 | 0.52 |
| ▸ | CCND1 | P24385 | 2/20 | 0.52 |
| ▸ | CCND2 | P30279 | 2/20 | 0.52 |
| ▸ | CCND3 | P30281 | 2/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | JUN | P05412 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377054 | 1.00 | EGFR (0.52) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL29371294 | 0.88 | MAPK10 (0.60) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL18376750 | 0.88 | MAPK10 (0.60) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL29370804 | 0.86 | MAPK10 (0.54) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL18376591 | 0.86 | MAPK10 (0.54) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL16514357 | 0.84 | MAPK10 (0.57) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL29847842 | 0.84 | CDK4 (0.49) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL16514846 | 0.84 | CDK4 (0.49) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL18377036 | 0.84 | MAPK10 (0.55) | EGFRCDK4CCND1RIPK2MAPK10 | |
| SCHEMBL29371938 | 0.84 | MAPK10 (0.55) | EGFRCDK4CCND1RIPK2MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |