Itraconzole

Itraconzole

SCHEMBL29371736

CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5COC(Cn6cncn6)(c6ccc(F)cc6F)O5)cc4)CC3)cc2)c1=O

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 17/20 0.79
ABCG2 Q9UNQ0 4/20 0.79
LMNA P02545 4/20 0.79
MAPT P10636 4/20 0.79
ABCB11 O95342 3/20 0.79
CYP8B1 Q9UNU6 3/20 0.79
CYP51A1 Q16850 3/20 0.79
FYN P06241 2/20 0.79
MEN1 O00255 2/20 0.79
ABCB1 P08183 2/20 0.79
MAPK1 P28482 2/20 0.79
KMT2A Q03164 2/20 0.79
HIF1A Q16665 2/20 0.79
CXCR1 P25024 1/20 0.79
TACR1 P25103 1/20 0.79
AVPR2 P30518 1/20 0.79
CCR4 P51679 1/20 0.79
PDE4D Q08499 1/20 0.79
CYP17A1 P05093 4/20 0.66
CYP19A1 P11511 4/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Itraconzole SCHEMBL1650334 1.00 CYP3A4 (0.79) CYP3A4ABCG2LMNAMAPTABCB11
Itraconzole SCHEMBL17739437 1.00 CYP3A4 (0.79) CYP3A4ABCG2LMNAMAPTABCB11
Itraconzole SCHEMBL10073778 1.00 CYP3A4 (0.79) CYP3A4ABCG2LMNAMAPTABCB11
Itraconzole SCHEMBL65702 1.00 CYP3A4 (0.79) CYP3A4ABCG2LMNAMAPTABCB11
Saperconazole SCHEMBL65701 1.00 CYP3A4 (0.79) CYP3A4ABCG2LMNAMAPTABCB11
Itraconzole SCHEMBL2615053 1.00 CYP3A4 (0.79) CYP3A4ABCG2LMNAMAPTABCB11
Itraconzole SCHEMBL12887924 1.00 CYP3A4 (0.79) CYP3A4ABCG2LMNAMAPTABCB11
Itraconzole SCHEMBL4149722 1.00 CYP3A4 (0.79) CYP3A4ABCG2LMNAMAPTABCB11
Saperconazole SCHEMBL28021428 0.99 CYP3A4 (0.78) CYP3A4ABCG2LMNAMAPTABCB11
Saperconazole SCHEMBL28133394 0.99 CYP3A4 (0.78) CYP3A4ABCG2LMNAMAPTABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3346998-B1 TOPICAL FILM DELIVERY SYSTEM SIDMAK LABORATORIES INDIA PVT LTD (IN) 2025-04-16 EP claimed
US-20260048049-A1 METHODS FOR TREATING CANCER USING INHALED ANGIOGENESIS INHIBITOR PULMATRIX OPERATING CO INC (US) 2026-02-19 US disclosed
EP-4680203-A1 COMPOSITIONS FOR SUSTAINED RELEASE OF POORLY SOLUBLE ACTIVE INGREDIENTS Prolevi Bio AB (SE) 2026-01-21 EP disclosed
US-20250312396-A1 Control of Cellular Redox Levels MCKENNA ELIZABETH (US) 2025-10-09 US disclosed
US-20250221928-A1 ANTIFUNGAL DRY POWDERS PULMATRIX OPERATING CO INC (US) 2025-07-10 US disclosed
EP-4580603-A2 SOFT CHEWABLE FORMULATIONS WITH ACTIVE INGREDIENTS Noble Pharma, LLC (US) 2025-07-09 EP disclosed
US-12285522-B2 Thermally gelling drug formulations UNM RAINFOREST INNOVATIONS (US) 2025-04-29 US disclosed
US-20250114411-A1 SOLID DOSAGE FORMS CONTAINING BACTERIA AND MICROBIAL EXTRACELLULAR VESICLES EVELO BIOSCIENCES INC (US) 2025-04-10 US disclosed
US-12268718-B2 Control of cellular redox levels LABYRINTH HOLDINGS LLC 2025-04-08 US disclosed
WO-2024189127-A1 COMPOSITIONS FOR SUSTAINED RELEASE OF POORLY SOLUBLE ACTIVE INGREDIENTS PROLEVI BIO AB (SE) 2024-09-19 WO disclosed
US-20230355523-A1 SELF-EMULSIFYING NANO-EMULSIONS MEDPHARM HOLDINGS LLC (US) 2023-11-09 US disclosed
US-20230355689-A1 SOLID DOSAGE FORMS CONTAINING BACTERIA AND MICROBIAL EXTRACELLULAR VESICLES EVELO BIOSCIENCES, INC. 2023-11-09 US disclosed
EP-4236919-A1 PHARMACEUTICAL COMPOSITION AND METHOD FOR ENHANCING SOLUBILITY OF POORLY SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS Merck Patent GmbH (DE) 2023-09-06 EP disclosed
US-11628162-B2 Methods of treating cancer with an FGFR inhibitor INCYTE CORPORATION (US) 2023-04-18 US disclosed
WO-2023049268-A1 SOLID DOSAGE FORMS CONTAINING BACTERIA AND MICROBIAL EXTRACELLULAR VESICLES EVELO BIOSCIENCES, INC. (US) 2023-03-30 WO disclosed
US-20230052945-A1 Thermally Gelling Drug Formulations UNM RAINFOREST INNOVATIONS (US) 2023-02-16 US disclosed
EP-4081195-A1 SOLID DOSAGE FORMS CONTAINING BACTERIA AND MICROBIAL EXTRACELLULAR VESICLES Evelo Biosciences, Inc. (US) 2022-11-02 EP disclosed
US-11464736-B2 Thermally gelling drug formulations UNM RAINFOREST INNOVATIONS (US) 2022-10-11 US disclosed
WO-2022090296-A1 PHARMACEUTICAL COMPOSITION AND METHOD FOR ENHANCING SOLUBILITY OF POORLY SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS MERCK PATENT GMBH (DE) 2022-05-05 WO disclosed
US-11235112-B2 Inhalable dry powders PULMATRIX OPERATING COMPANY, INC. (US) 2022-02-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260048049-A1 METHODS FOR TREATING CANCER USING INHALED ANGIOGENESIS INHIBITOR VEGFA, EGFR, KDR CYP3A4 3178/4885ABCG2 2689/4885LMNA 3574/4885
US-11628162-B2 Methods of treating cancer with an FGFR inhibitor FGFR2, FGFR3, FGFR1 CYP3A4 4829/4885ABCG2 2048/4885LMNA 3783/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.