Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.51 |
| ▸ | JAK3 | P52333 | 20/20 | 0.51 |
| ▸ | JAK2 | O60674 | 11/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29610715 | 0.91 | JAK1 (0.48) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL29752405 | 0.85 | JAK1 (0.43) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL28944384 | 0.85 | JAK1 (0.43) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL28778514 | 0.81 | JAK1 (0.52) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL29610484 | 0.80 | JAK1 (0.68) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL15389136 | 0.80 | JAK1 (0.68) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL29780520 | 0.80 | SYK (0.44) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL1395335 | 0.80 | SYK (0.44) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL28778597 | 0.79 | JAK1 (0.44) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL28778570 | 0.77 | JAK1 (0.42) | JAK1JAK3JAK2CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022023456-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NANO EMBEDDED MICROPARTICLES AND METHODS OF USE | ASTRAZENECA AB (SE) | 2022-02-03 | — | — | WO | claimed |
| WO-2022023456-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NANO EMBEDDED MICROPARTICLES AND METHODS OF USE | ASTRAZENECA AB (SE) | 2022-02-03 | — | — | WO | disclosed |