Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | FLT3 | P36888 | 7/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.41 |
| ▸ | NRAS | P01111 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24231674 | 1.00 | KDR (0.49) | KDRFLT3GABRA1GABRG2GABRB3 | |
| SCHEMBL29372765 | 0.86 | FYN (0.44) | KDRFLT3GABRA1GABRG2GABRB3 | |
| SCHEMBL24231555 | 0.86 | FYN (0.44) | KDRFLT3GABRA1GABRG2GABRB3 | |
| SCHEMBL3330148 | 0.84 | KDR (0.46) | KDRFLT3 | |
| SCHEMBL26359555 | 0.78 | FLT3 (0.62) | KDRFLT3GABRA1GABRG2GABRB3 | |
| SCHEMBL2660202 | 0.78 | JMJD6 (0.42) | KDRFGFR3HPGD | |
| SCHEMBL376136 | 0.77 | CSNK2A1 (0.39) | KDRFLT3FGFR3HPGD | |
| SCHEMBL25997433 | 0.77 | IRAK4 (0.67) | KDRFLT3NRASIRAK4 | |
| SCHEMBL24231536 | 0.77 | FLT3 (0.50) | KDRFLT3GABRA1GABRG2GABRB3 | |
| SCHEMBL29373196 | 0.77 | FLT3 (0.50) | KDRFLT3GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022026935-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2022-02-03 | — | — | WO | disclosed |