SCHEMBL2937387

SCHEMBL2937387

CSc1cc(Oc2ccnc3[nH]c(=O)cnc23)ccc1NC(=O)O

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BRAF P15056 20/20 0.69
KCNH2 Q12809 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29397104 0.91 BRAF (0.68) BRAF
SCHEMBL28690852 0.89 BRAF (0.57) BRAFKCNH2
SCHEMBL3751692 0.88 BRAF (0.66) BRAFKCNH2
SCHEMBL29662245 0.88 BRAF (0.66) BRAFKCNH2
SCHEMBL28707059 0.88 BRAF (0.56) BRAFKCNH2
SCHEMBL28698609 0.86 BRAF (0.55) BRAFKCNH2
SCHEMBL2926446 0.85 BRAF (0.71) BRAF
SCHEMBL28686052 0.85 BRAF (0.58) BRAFKCNH2
SCHEMBL16740695 0.85 BRAF (0.70) BRAFKCNH2
SCHEMBL22919872 0.83 BRAF (0.67) BRAFKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114144410-A Polyarylurea derivatives and their use in the treatment of muscular diseases 阿纳格纳斯生物技术股份有限公司 2022-03-04 CN disclosed
EP-2229391-A1 PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE Cancer Research Technology Limited (GB) 2010-09-22 EP disclosed
WO-2009077766-A1 PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2009-06-25 WO disclosed