SCHEMBL29374178

SCHEMBL29374178

Cc1nc(N2CCC3(CC2)CO[C@@H](C)[C@H]3N)c(CO)nc1-c1cccc(Cl)c1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PTPN11 Q06124 20/20 1.00
KCNH2 Q12809 2/20 1.00
EGFR P00533 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21154462 1.00 PTPN11 (1.00) PTPN11KCNH2EGFR
SCHEMBL21154418 1.00 PTPN11 (1.00) PTPN11KCNH2EGFR
SCHEMBL30295961 1.00 PTPN11 (1.00) PTPN11KCNH2EGFR
SCHEMBL29478950 1.00 PTPN11 (1.00) PTPN11KCNH2EGFR
SCHEMBL19785503 1.00 PTPN11 (1.00) PTPN11KCNH2EGFR
SCHEMBL25094875 1.00 PTPN11 (1.00) PTPN11KCNH2EGFR
SCHEMBL21154556 1.00 PTPN11 (1.00) PTPN11KCNH2EGFR
SCHEMBL20807077 0.93 PTPN11 (0.87) PTPN11KCNH2EGFR
SCHEMBL24233670 0.91 PTPN11 (0.84) PTPN11KCNH2EGFR
SCHEMBL20807079 0.91 PTPN11 (0.83) PTPN11KCNH2EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1018 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144799-A1 COMPOSITION COMPRISING A FIRST RAS INHIBITOR, SECOND RAS INHIBITOR AND A SHP2 INHIBITOR FOR USE IN THE TREATMENT OF CANCER Revolution Medicines, Inc. (US) 2026-05-28 US claimed
CN-122074043-A Combination therapy with KRAS modulators 光达治疗公司 2026-05-22 CN claimed
WO-2026101937-A1 COMPOSITIONS COMPRISING (Z)-ENDOXIFEN AND A CDK4/6 INHIBITOR AND METHODS OF USE THEREOF ATOSSA THERAPEUTICS, INC. (US) 2026-05-15 WO claimed
US-20250262194-A1 PHARMACEUTICAL FOR TREATING OR PREVENTING CANCER CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2025-08-21 US claimed
EP-4601649-A1 COMPOSITION COMPRISING A FIRST RAS INHIBITOR, SECOND RAS INHIBITOR AND A SHP2 INHIBITOR FOR USE IN THE TREATMENT OF CANCER Revolution Medicines, Inc. (US) 2025-08-20 EP claimed
US-12377101-B2 Combination therapies Mirati Therapeutics, Inc. (US) 2025-08-05 US claimed
US-20250228938-A1 THE COMBINATION OF MACROPHAGE-DIRECTED IMMUNOTHERAPY AND TARGETED AGENTS FOR TREATMENT OF CANCER WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2025-07-17 US claimed
US-20250228834-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF COLON AND LUNG CANCER HEPAREGENIX GMBH (DE) 2025-07-17 US claimed
US-20250177389-A1 METHOD OF TREATMENT INCLUDING KRAS G12C INHIBITORS AND SHP2 INHIBITORS ELI LILLY AND COMPANY 2025-06-05 US claimed
WO-2025106901-A1 COMBINATION CANCER THERAPIES WITH A KRAS MODULATOR AND AN RTK-MAPK PATHWAY INHIBITOR QUANTA THERAPEUTICS, INC. (US) 2025-05-22 WO claimed
WO-2022226145-A1 METHOD AND COMPOSITION FOR THE PREVENTION OR TREATMENT OF OSTEOARTHRITIS HOSPITAL RHODE ISLAND (US) 2022-10-27 WO claimed
WO-2022170060-A1 COMBINATION THERAPY FOR TREATING ABNORMAL CELL GROWTH VERASTEM, INC. (US) 2022-08-11 WO claimed
WO-2022103834-A1 COMBINATIONS OF METAP2 INHIBITORS AND CDK4/6 INHIBITORS FOR THE TREATMENT OF CANCER SYNDEVRX, INC. (US) 2022-05-19 WO claimed
CN-114437065-A Heterocyclic compounds, their preparation and use 益方生物科技(上海)股份有限公司 2022-05-06 CN claimed
EP-3990476-A1 FLT3L-FC FUSION PROTEINS AND METHODS OF USE GILEAD SCIENCES, INC. (US) 2022-05-04 EP claimed
WO-2022087149-A2 INTERLEUKIN-2-FC FUSION PROTEINS AND METHODS OF USE GILEAD SCIENCES, INC. (US) 2022-04-28 WO claimed
CN-114245807-A FLT3L-FC fusion proteins and methods of use 吉利德科学公司 2022-03-25 CN claimed
WO-2022060583-A1 USE OF SOS1 INHIBITORS TO TREAT MALIGNANCIES WITH SHP2 MUTATIONS Revolution Medicines, Inc. (US) 2022-03-24 WO claimed
US-20220079947-A1 COMBINATION THERAPIES Mirati Therapeutics, Inc. 2022-03-17 US claimed
US-20220062260-A1 COMBINATION THERAPY FOR TREATMENT OF LKB1 DEFICIENT CANCERS NEW YORK UNIVERSITY 2022-03-03 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250228834-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF COLON AND LUNG CANCER KRAS, MAPK4, NRAS PTPN11 66/4885KCNH2 3984/4885EGFR 161/4885
US-20260144799-A1 COMPOSITION COMPRISING A FIRST RAS INHIBITOR, SECOND RAS INHIBITOR AND A SHP2 INHIBITOR FOR USE IN THE TREATMENT OF CANCER PDCD1, CD274, PTPN1 PTPN11 17/4885KCNH2 2775/4885EGFR 250/4885
US-20250262194-A1 PHARMACEUTICAL FOR TREATING OR PREVENTING CANCER KRAS, NRAS, TP53 PTPN11 27/4885KCNH2 4220/4885EGFR 130/4885
US-20220079947-A1 COMBINATION THERAPIES KRAS, NRAS, HRAS PTPN11 9/4885KCNH2 4389/4885EGFR 234/4885
US-12377101-B2 Combination therapies KRAS, NRAS, HRAS PTPN11 9/4885KCNH2 4389/4885EGFR 234/4885
US-20250177389-A1 METHOD OF TREATMENT INCLUDING KRAS G12C INHIBITORS AND SHP2 INHIBITORS KRAS, NRAS, HRAS PTPN11 12/4885KCNH2 3088/4885EGFR 128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.