Sertraline

Sertraline

SCHEMBL29374222

CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC6A4

The experimentally established mechanism targets of Sertraline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 known ✓ P31645 5/20 1.00
MEN1 O00255 5/20 1.00
KMT2A Q03164 5/20 1.00
CYP3A4 P08684 5/20 1.00
SLC6A2 P23975 5/20 1.00
SLC6A3 Q01959 5/20 1.00
CYP1A2 P05177 3/20 1.00
CYP2C19 P33261 3/20 1.00
NPC1 O15118 2/20 1.00
CYP2D6 P10635 2/20 1.00
MTOR P42345 2/20 1.00
RAB9A P51151 2/20 1.00
MLNR O43193 1/20 1.00
NR1I2 O75469 1/20 1.00
ABCB11 O95342 1/20 1.00
ESR1 P03372 1/20 1.00
CHRM2 P08172 1/20 1.00
CHRM4 P08173 1/20 1.00
ABCB1 P08183 1/20 1.00
ADRB1 P08588 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sertraline SCHEMBL29690831 1.00 MEN1 (1.00) MEN1KMT2ACYP3A4SLC6A2SLC6A4
Sertraline SCHEMBL3841967 1.00 MEN1 (1.00) MEN1KMT2ACYP3A4SLC6A2SLC6A4
Sertraline SCHEMBL14028076 1.00 MEN1 (1.00) MEN1KMT2ACYP3A4SLC6A2SLC6A4
Sertraline SCHEMBL3885286 1.00 MEN1 (1.00) MEN1KMT2ACYP3A4SLC6A2SLC6A4
Sertraline SCHEMBL7922153 1.00 MEN1 (1.00) MEN1KMT2ACYP3A4SLC6A2SLC6A4
Sertraline SCHEMBL3947169 1.00 MEN1 (1.00) MEN1KMT2ACYP3A4SLC6A2SLC6A4
Sertraline SCHEMBL30244837 1.00 MEN1 (1.00) MEN1KMT2ACYP3A4SLC6A2SLC6A4
Sertraline SCHEMBL3856872 1.00 MEN1 (1.00) MEN1KMT2ACYP3A4SLC6A2SLC6A4
Sertraline SCHEMBL137619 1.00 MEN1 (1.00) MEN1KMT2ACYP3A4SLC6A2SLC6A4
Sertraline SCHEMBL137618 1.00 MEN1 (1.00) MEN1KMT2ACYP3A4SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
EP-3713986-B1 COMPOSITION REBIO TECH OY (FI) 2026-04-01 EP claimed
EP-4209246-B1 METHOD OF MANUFACTURING OF A PARTICLE-ATTACHED MICRONEEDLE QUADMEDICINE INC (KR) 2026-02-18 EP claimed
EP-3507371-B1 COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM UNIV RUTGERS (US) 2026-01-28 EP claimed
EP-3931189-B1 AZEPINO-INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS UNIV CALIFORNIA (US) 2025-12-24 EP claimed
EP-4208466-B1 HIGH AFFINITY MACROCYCLIC FKB51-INHIBITORS FOR TREATMENT OF PSYCHIATRIC DISORDERS UNIV DARMSTADT TECH (DE) 2025-06-11 EP claimed
EP-3603674-B1 COMBINATION OF MORPHINAN COMPOUNDS AND ANTIDEPRESSANT FOR THE TREATMENT OF INTRACTABLE AND CHRONIC PAIN SUN PHARMACEUTICAL IND INC (US) 2025-02-26 EP claimed
EP-3946296-B9 EXTENDED RELEASE PHARMACEUTICAL FORMULATION DOUGLAS PHARMACEUTICALS LTD (NZ) 2024-12-25 EP claimed
EP-3294337-B1 TREATMENT OF DEBILITATING FATIGUE BY COMBINED USE OF 3(S)-3-[3-(METHYLSULFONYL)PHENYL]-1- PROPYLPIPERIDINE AND AN ANTI-DEPRESSIVE AGENT ARVID CARLSSON RES AB (SE) 2024-12-18 EP claimed
EP-4023222-B1 NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATOR FOR TREATMENT OF 22Q SYNDROME CHILDRENS HOSPITAL PHILADELPHIA (US) 2024-12-18 EP claimed
EP-3151837-B1 PROTECTIVE EFFECT OF DMPC, DMPG, DMPC/DMPG, EGPG, LYSOPG AND LYSOPC AGAINST DRUGS THAT CAUSE CHANNELOPATHIES SIGNPATH PHARMA INC (US) 2023-03-15 EP claimed
WO-2022173841-A9 METHODS OF MODELING IN VIVO EFFICACY OF DRUG COMBINATIONS FOR TREATMENT OF VIRAL INFECTIONS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2023-03-02 WO claimed
EP-4139929-A1 METHOD FOR PROVIDING A MEDICATION COMBINATION AND DATA CARRIER WITH SOFTWARE Universität Ulm (DE) 2023-03-01 EP claimed
EP-3891505-B1 A METHOD FOR MEASURING A CONCENTRATION OF A BIOMARKER/ANALYTE IN BLOOD FROM MAMMALS REDHOTDIAGNOSTICS AB (SE) 2022-11-30 EP claimed
EP-3337456-B1 LIPOSOMES WITH GINSENOSIDE AS MEMBRANE MATERIAL AND PREPARATIONS AND USE THEREOF SHANGHAI GINPOSOME PHARMATECH CO LTD (CN) 2022-10-26 EP claimed
EP-4057999-A1 PROCESS FOR PREPARING NANO- OR MICROPARTICLES COMPRISING A CARRIER-POLYMER AND ONE OR MORE BIOLOGICALLY ACTIVE INGREDIENTS Evonik Operations GmbH (DE) 2022-09-21 EP claimed
EP-3071194-B1 PHARMACOLOGICAL TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER USING STIRIPENTOL OR A SIMILAR COMPOUND BIOCODEX (FR) 2022-08-03 EP claimed
EP-3583076-B1 ENZYMATIC PURIFICATION OF TOILET WATER PHAREM BIOTECH AB (SE) 2022-06-29 EP claimed
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
EP-3454853-B1 TREATMENT OF ALCOHOLISM AND DEPRESSION USING IBUDILAST MEDICINOVA INC (US) 2022-05-18 EP claimed