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SCHEMBL2937448

SCHEMBL2937448

Cc1c(Nc2c(C#N)cncc2C=Cc2ccc(OCCN3CCCC3)cc2)ccc2[nH]ccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ PRKCQ Q04759 20/20 1.00
▸ PRKCD Q05655 20/20 1.00
▸ PRKCB P05771 2/20 0.76
▸ PRKCH P24723 2/20 0.76
▸ PRKCE Q02156 2/20 0.76
▸ LCK P06239 1/20 0.76
▸ LYN P07948 1/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2937724 1.00 PRKCQ (1.00) PRKCQPRKCDPRKCBPRKCHPRKCE
SCHEMBL2935011 0.95 PRKCQ (1.00) PRKCQPRKCDPRKCBPRKCHPRKCE
SCHEMBL2927002 0.92 PRKCQ (0.85) PRKCQPRKCDPRKCBPRKCHPRKCE
SCHEMBL2927005 0.92 PRKCQ (0.85) PRKCQPRKCDPRKCBPRKCHPRKCE
SCHEMBL2932031 0.91 PRKCQ (1.00) PRKCQPRKCDPRKCBPRKCHPRKCE
SCHEMBL2935383 0.89 PRKCQ (0.81) PRKCQPRKCDPRKCBPRKCHPRKCE
SCHEMBL2935387 0.89 PRKCQ (0.81) PRKCQPRKCDPRKCBPRKCHPRKCE
SCHEMBL2930057 0.89 PRKCQ (1.00) PRKCQPRKCDPRKCBPRKCHPRKCE
SCHEMBL2935962 0.89 PRKCQ (1.00) PRKCQPRKCDPRKCBPRKCHPRKCE
SCHEMBL2933695 0.88 PRKCQ (0.79) PRKCQPRKCDPRKCBPRKCHPRKCE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2229377-A1 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS Wyeth LLC (US) 2010-09-22 — — EP disclosed
WO-2009076602-A1 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS WYETH (US) 2009-06-18 — — WO disclosed