Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 13/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3213329 | 0.91 | PTPN1 (0.48) | PTPN1PTPN2 | |
| SCHEMBL3213345 | 0.91 | PTPN1 (0.48) | PTPN1PTPN2 | |
| SCHEMBL2928485 | 0.87 | PTPN1 (0.52) | PTPN1PTPN2 | |
| SCHEMBL2934467 | 0.85 | PTPN1 (0.47) | PTPN1PTPN2 | |
| SCHEMBL2936953 | 0.85 | PTPN1 (0.48) | PTPN1PTPN2 | |
| SCHEMBL2933680 | 0.81 | PTPN1 (0.54) | PTPN1PTPN2 | |
| SCHEMBL4785520 | 0.80 | PTPN1 (0.46) | PTPN1PTPN2CXCR4 | |
| SCHEMBL4785526 | 0.80 | PTPN1 (0.46) | PTPN1PTPN2CXCR4 | |
| SCHEMBL3226863 | 0.78 | PTPN1 (0.44) | PTPN1PTPN2 | |
| SCHEMBL2936665 | 0.78 | PTPN1 (0.44) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227245-A2 | COMBINATION OF PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND HUMAN GROWTH HORMONE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | Novartis AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009068689-A2 | COMBINATION OF PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND HUMAN GROWTH HORMONE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | NOVARTIS AG (CH) | 2009-06-04 | — | — | WO | disclosed |