Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 18/20 | 0.81 |
| ▸ | BRD2 | P25440 | 3/20 | 0.81 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.81 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.81 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.81 |
| ▸ | SMCHD1 | A6NHR9 | 1/20 | 0.81 |
| ▸ | MYO1G | B0I1T2 | 1/20 | 0.81 |
| ▸ | AIP | O00170 | 1/20 | 0.81 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.81 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.81 |
| ▸ | CDC7 | O00311 | 1/20 | 0.81 |
| ▸ | SAP18 | O00422 | 1/20 | 0.81 |
| ▸ | KPNA3 | O00505 | 1/20 | 0.81 |
| ▸ | PPP6C | O00743 | 1/20 | 0.81 |
| ▸ | TCERG1 | O14776 | 1/20 | 0.81 |
| ▸ | UBE2L6 | O14933 | 1/20 | 0.81 |
| ▸ | PPP1R12A | O14974 | 1/20 | 0.81 |
| ▸ | U2SURP | O15042 | 1/20 | 0.81 |
| ▸ | SETD1A | O15047 | 1/20 | 0.81 |
| ▸ | ARPC1B | O15143 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14756861 | 1.00 | BRD4 (0.81) | BRD4BRD2HDAC1HDAC2BRD3 | |
| SCHEMBL1885561 | 0.94 | BRD4 (0.74) | BRD4BRD2HDAC1HDAC2BRD3 | |
| SCHEMBL15981812 | 0.92 | BRD4 (0.79) | BRD4BRD2HDAC1HDAC2BRD3 | |
| SCHEMBL29377393 | 0.92 | BRD4 (0.79) | BRD4BRD2HDAC1HDAC2BRD3 | |
| SCHEMBL1869987 | 0.92 | BRD4 (0.79) | BRD4BRD2HDAC1HDAC2BRD3 | |
| SCHEMBL25255616 | 0.92 | BRD4 (0.78) | BRD4BRD2HDAC1HDAC2BRD3 | |
| SCHEMBL15981799 | 0.92 | BRD4 (0.78) | BRD4BRD2HDAC1HDAC2BRD3 | |
| SCHEMBL29380378 | 0.92 | BRD4 (0.78) | BRD4BRD2HDAC1HDAC2BRD3 | |
| Molibresib SCHEMBL19459525 | 0.91 | BRD4 (0.97) | BRD4BRD2HDAC1HDAC2BRD3 | |
| SCHEMBL15981805 | 0.91 | BRD4 (0.74) | BRD4BRD2HDAC1HDAC2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4192825-A2 | THERAPEUTICALLY USEFUL CURE-PRO MOLECULES FOR E3 LIGASE MEDIATED DEGRADATION OF PROTEINS, AND METHODS OF MAKING AND USING THEM | Cornell University (US) | 2023-06-14 | — | — | EP | disclosed |
| EP-4192504-A2 | THERAPEUTIC CURE-PRO COMPOUNDS FOR TARGETED DEGRADATION OF BET DOMAIN PROTEINS, AND METHODS OF MAKING AND USING THEM | Cornell University (US) | 2023-06-14 | — | — | EP | disclosed |
| WO-2022031777-A2 | THERAPEUTICALLY USEFUL CURE-PRO MOLECULES FOR E3 LIGASE MEDIATED DEGRADATION OF PROTEINS, AND METHODS OF MAKING AND USING THEM | CORNELL UNIVERSITY (US) | 2022-02-10 | — | — | WO | disclosed |
| WO-2022031774-A2 | THERAPEUTIC CURE-PRO COMPOUNDS FOR TARGETED DEGRADATION OF BET DOMAIN PROTEINS, AND METHODS OF MAKING AND USING THEM | CORNELL UNIVERSITY (US) | 2022-02-10 | — | — | WO | disclosed |