SCHEMBL29378263

SCHEMBL29378263

CN1CCN(c2ccc(Nc3cc(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)cn(C)c3=O)nc2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
BTK Q06187 20/20 1.00
YES1 P07947 1/20 1.00
FGR P09769 1/20 1.00
TEC P42680 1/20 1.00
BMX P51813 1/20 1.00
KCNH2 Q12809 1/20 1.00
SLK Q9H2G2 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29354649 1.00 BTK (1.00) BTKYES1FGRTECBMX
SCHEMBL1724904 1.00 BTK (1.00) BTKYES1FGRTECBMX
SCHEMBL16173690 0.96 BTK (0.93) BTKYES1FGRTECBMX
SCHEMBL1726979 0.94 BTK (1.00) BTKYES1FGRTECBMX
SCHEMBL22945745 0.94 BTK (0.92) BTKYES1FGRTECBMX
SCHEMBL22946024 0.94 BTK (0.89) BTKYES1FGRTECBMX
SCHEMBL3041622 0.94 BTK (0.88) BTKYES1FGRTECBMX
SCHEMBL3058691 0.93 BTK (0.87) BTKYES1FGRTECBMX
SCHEMBL1727048 0.93 BTK (1.00) BTKYES1FGRTECBMX
SCHEMBL22946141 0.92 BTK (0.87) BTKYES1FGRTECBMX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022232420-A1 CERTAIN N-(1-CYANO-2-PHENYLETHYL)-1,4-OXAZEPANE-2-CARBOXAMIDES FOR TREATING CANCER INSMED INCORPORATED (US) 2022-11-03 WO claimed
WO-2022081512-A1 COMPOSITIONS AND METHODS OF TREATMENT OF NEUROINFLAMMATORY DISEASES WITH BRUTON'S TYROSINE KINASE INHIBITORS SYNUBI PHARMACEUTICALS LLC (US) 2022-04-21 WO claimed
CN-122059926-A Heterocyclic degradation determinants for target protein degradation C4医药公司 2026-05-19 CN disclosed
EP-4735452-A2 HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS PROTEIN Merck Patent GmbH (DE) 2026-05-06 EP disclosed
EP-4735438-A2 HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS Merck Patent GmbH (DE) 2026-05-06 EP disclosed
EP-4717317-A2 N/O-LINKED DEGRONS AND DEGRONIMERS FOR PROTEIN DEGRADATION C4 Therapeutics, Inc. (US) 2026-04-01 EP disclosed
US-20260041685-A1 METHODS OF TREATING INDOLENT SYSTEMIC MASTOCYTOSIS TELIOS PHARMA INC. (US) 2026-02-12 US disclosed
EP-4665720-A2 ISOINDOLINONE GLUTARIMIDE AND PHENYL GLUTARIMIDE ANALOGS AS DEGRADERS OF RET KINASE Bristol-Myers Squibb Company (US) 2025-12-24 EP disclosed
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 EP disclosed
EP-4652997-A2 CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS Pharmacosmos Holding A/s (DK) 2025-11-26 EP disclosed
US-12414950-B1 Methods of treating indolent systemic mastocytosis TELIOS PHARMA INC. (US) 2025-09-16 US disclosed
WO-2022081925-A1 TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 C4 THERAPEUTICS, INC. (US) 2022-04-21 WO disclosed
WO-2022081927-A1 TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY C4 THERAPEUTICS, INC. (US) 2022-04-21 WO disclosed
WO-2022081928-A1 TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS C4 THERAPEUTICS, INC. (US) 2022-04-21 WO disclosed
WO-2022081512-A1 COMPOSITIONS AND METHODS OF TREATMENT OF NEUROINFLAMMATORY DISEASES WITH BRUTON'S TYROSINE KINASE INHIBITORS SYNUBI PHARMACEUTICALS LLC (US) 2022-04-21 WO disclosed
CN-105682658-B Cancer therapy using PI3 kinase subtype modulators 无限药品公司 2022-04-05 CN disclosed
WO-2022066774-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ACHILLION PHARMACEUTICALS, INC. (US) 2022-03-31 WO disclosed
WO-2022035997-A1 IN VIVO ASSEMBLY OF ASGPR BINDING THERAPEUTICS AVILAR THERAPEUTICS, INC. (US) 2022-02-17 WO disclosed
WO-2022032132-A1 ADVANTAGEOUS THERAPIES FOR DISORDERS MEDIATED BY IKAROS OR AIOLOS C4 THERAPEUTICS, INC. (US) 2022-02-10 WO disclosed
WO-2022032026-A1 COMPOUNDS FOR TARGETED DEGRADATION OF RET C4 THERAPEUTICS, INC. (US) 2022-02-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260041685-A1 METHODS OF TREATING INDOLENT SYSTEMIC MASTOCYTOSIS BTK, KIT, LYN BTK 1/4885YES1 15/4885FGR 233/4885
US-12414950-B1 Methods of treating indolent systemic mastocytosis BTK, LYN, ABL1 BTK 1/4885YES1 50/4885FGR 416/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.