Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | ITGB2 | P05107 | 9/20 | 0.57 |
| ▸ | ICAM1 | P05362 | 9/20 | 0.57 |
| ▸ | ITGAL | P20701 | 9/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1020786 | 1.00 | HDAC1 (0.61) | HDAC1HDAC8HDAC6ITGB2ICAM1 | |
| SCHEMBL5019656 | 1.00 | HDAC1 (0.61) | HDAC1HDAC8HDAC6ITGB2ICAM1 | |
| SCHEMBL1020787 | 1.00 | HDAC1 (0.61) | HDAC1HDAC8HDAC6ITGB2ICAM1 | |
| Hydrochloric Acid SCHEMBL29478485 | 0.99 | HDAC6 (0.60) | HDAC1HDAC8HDAC6ITGB2ICAM1 | |
| SCHEMBL23666454 | 0.93 | HDAC1 (0.65) | HDAC1HDAC8HDAC6ITGB2ICAM1 | |
| SCHEMBL17132276 | 0.91 | KMT2A (0.51) | HDAC1HDAC8HDAC6ITGB2ICAM1 | |
| SCHEMBL6763024 | 0.87 | HDAC1 (0.67) | HDAC1HDAC8HDAC6ITGB2ICAM1 | |
| SCHEMBL6763018 | 0.87 | HDAC1 (0.67) | HDAC1HDAC8HDAC6ITGB2ICAM1 | |
| SCHEMBL6759553 | 0.87 | ITGB2 (0.74) | HDAC1HDAC8HDAC6ITGB2ICAM1 | |
| SCHEMBL6759557 | 0.87 | ITGB2 (0.74) | HDAC1HDAC8HDAC6ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114144229-A | Methods and materials for gender-dependent treatment of cardiovascular dysfunction | 梅约医学教育与研究基金会 | 2022-03-04 | — | — | CN | claimed |
| EP-3952992-A1 | METHODS AND MATERIALS FOR GENDER-DEPENDENT TREATMENT OF CARDIOVASCULAR DYSFUNCTION | Mayo Foundation for Medical Education and Research (US) | 2022-02-16 | — | — | EP | claimed |
| CN-114144229-A | Methods and materials for gender-dependent treatment of cardiovascular dysfunction | 梅约医学教育与研究基金会 | 2022-03-04 | — | — | CN | disclosed |
| EP-3952992-A1 | METHODS AND MATERIALS FOR GENDER-DEPENDENT TREATMENT OF CARDIOVASCULAR DYSFUNCTION | Mayo Foundation for Medical Education and Research (US) | 2022-02-16 | — | — | EP | disclosed |