Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 20/20 | 0.63 |
| ▸ | WDR77 | Q9BQA1 | 20/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21355965 | 1.00 | PRMT5 (0.63) | PRMT5WDR77 | |
| SCHEMBL21367136 | 0.93 | PRMT5 (0.57) | PRMT5WDR77 | |
| SCHEMBL21356239 | 0.93 | PRMT5 (0.61) | PRMT5WDR77 | |
| SCHEMBL29381289 | 0.93 | PRMT5 (0.61) | PRMT5WDR77 | |
| SCHEMBL29383078 | 0.93 | PRMT5 (0.61) | PRMT5WDR77 | |
| SCHEMBL22517602 | 0.93 | PRMT5 (0.61) | PRMT5WDR77 | |
| SCHEMBL21355754 | 0.93 | PRMT5 (0.61) | PRMT5WDR77 | |
| SCHEMBL29380881 | 0.92 | PRMT5 (0.75) | PRMT5WDR77 | |
| SCHEMBL21356339 | 0.92 | PRMT5 (0.75) | PRMT5WDR77 | |
| SCHEMBL21355973 | 0.91 | PRMT5 (0.74) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765461-B1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2023-08-30 | — | — | EP | disclosed |
| EP-3946352-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 | Prelude Therapeutics, Incorporated (US) | 2022-02-09 | — | — | EP | disclosed |