Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 20/20 | 0.64 |
| ▸ | WDR77 | Q9BQA1 | 20/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21356130 | 1.00 | PRMT5 (0.64) | PRMT5WDR77 | |
| SCHEMBL22517569 | 0.95 | PRMT5 (0.65) | PRMT5WDR77 | |
| SCHEMBL21356297 | 0.95 | PRMT5 (0.65) | PRMT5WDR77 | |
| SCHEMBL29383642 | 0.92 | PRMT5 (0.76) | PRMT5WDR77 | |
| SCHEMBL21356257 | 0.92 | PRMT5 (0.76) | PRMT5WDR77 | |
| SCHEMBL21369156 | 0.92 | PRMT5 (0.76) | PRMT5WDR77 | |
| SCHEMBL24489710 | 0.91 | PRMT5 (0.63) | PRMT5WDR77 | |
| SCHEMBL29381320 | 0.91 | PRMT5 (0.63) | PRMT5WDR77 | |
| SCHEMBL21356189 | 0.91 | PRMT5 (0.63) | PRMT5WDR77 | |
| SCHEMBL21355754 | 0.91 | PRMT5 (0.61) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114829370-A | Selective inhibitors of protein arginine methyltransferase 5(PRMT5) | 普莱鲁德疗法有限公司 | 2022-07-29 | — | — | CN | disclosed |
| EP-4031555-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | Prelude Therapeutics, Incorporated (US) | 2022-07-27 | — | — | EP | disclosed |
| EP-3946352-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 | Prelude Therapeutics, Incorporated (US) | 2022-02-09 | — | — | EP | disclosed |