Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25422577 | 1.00 | KDM1A (0.50) | KDM1APDE7ATNKSTNKS2KDM4E | |
| SCHEMBL15523144 | 0.94 | KDM1A (0.51) | KDM1APDE7ATNKSTNKS2ALDH1A1 | |
| SCHEMBL3934411 | 0.90 | KDM1A (0.55) | KDM1APDE7ATNKSTNKS2KDM4E | |
| SCHEMBL397157 | 0.86 | KDM1A (0.51) | KDM1ATNKSTNKS2ALDH1A1MEN1 | |
| SCHEMBL29386699 | 0.82 | TNKS (0.44) | KDM1APDE7ATNKSTNKS2KDM4E | |
| SCHEMBL21537943 | 0.82 | TNKS (0.44) | KDM1APDE7ATNKSTNKS2KDM4E | |
| SCHEMBL20469127 | 0.82 | TNKS (0.44) | KDM1APDE7ATNKSTNKS2KDM4E | |
| SCHEMBL1795624 | 0.82 | TNKS (0.44) | KDM1APDE7ATNKSTNKS2KDM4E | |
| SCHEMBL13209513 | 0.81 | KDM1A (0.47) | KDM1APDE7ATNKSTNKS2ALDH1A1 | |
| SCHEMBL1828877 | 0.80 | TNKS (0.45) | KDM1APDE7ATNKSTNKS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4192957-A2 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| CN-116113698-A | TRPML modulators | 卡斯玛治疗公司 | 2023-05-12 | — | — | CN | disclosed |
| WO-2022032073-A2 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2022-02-10 | — | — | WO | disclosed |