Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.57 |
| ▸ | SMO | Q99835 | 3/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2940402 | 0.90 | IGF1R (0.59) | IGF1RSMOMAPK1HDAC1HDAC6 | |
| SCHEMBL2939858 | 0.87 | IGF1R (0.59) | IGF1RSMO | |
| SCHEMBL2941452 | 0.87 | SMO (0.42) | IGF1RSMO | |
| SCHEMBL2942468 | 0.85 | IGF1R (0.61) | IGF1RSMOPTGDR2 | |
| SCHEMBL2938849 | 0.85 | IGF1R (0.61) | IGF1RSMOPTGDR2 | |
| SCHEMBL2938301 | 0.84 | PPARD (0.40) | IGF1RNPY5RMAPK1PTGDR2 | |
| SCHEMBL2934055 | 0.84 | IGF1R (0.57) | IGF1R | |
| SCHEMBL2936925 | 0.83 | IGF1R (0.56) | IGF1RSMOPTGDR2 | |
| SCHEMBL2939240 | 0.83 | IGF1R (0.55) | IGF1RSMOHDAC6 | |
| SCHEMBL2940949 | 0.83 | IGF1R (0.58) | IGF1RSMOPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |