Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29384830 | 0.83 | PARP1 (0.50) | TLR8GPR119TLR9TLR7RET | |
| SCHEMBL22530379 | 0.83 | TLR9 (0.46) | TLR8GPR119TLR9TLR7 | |
| SCHEMBL22547757 | 0.82 | TLR9 (0.57) | TLR8GPR119TLR9TLR7 | |
| SCHEMBL22530090 | 0.82 | TLR9 (0.57) | TLR8GPR119TLR9TLR7 | |
| SCHEMBL29421752 | 0.82 | TLR9 (0.57) | TLR8GPR119TLR9TLR7 | |
| SCHEMBL22530091 | 0.82 | TLR9 (0.57) | TLR8GPR119TLR9TLR7 | |
| SCHEMBL22530089 | 0.82 | TLR9 (0.57) | TLR8GPR119TLR9TLR7 | |
| SCHEMBL22547749 | 0.82 | TLR9 (0.57) | TLR8GPR119TLR9TLR7 | |
| SCHEMBL22547758 | 0.82 | TLR9 (0.57) | TLR8GPR119TLR9TLR7 | |
| SCHEMBL29421761 | 0.82 | TLR9 (0.57) | TLR8GPR119TLR9TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057754-B | Nitrogen-containing bridged ring derivatives, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-114057754-A | Nitrogen-containing bridged ring derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-02-18 | — | — | CN | disclosed |