Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.57 |
| ▸ | JAK1 | P23458 | 9/20 | 0.53 |
| ▸ | JAK2 | O60674 | 9/20 | 0.53 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21847334 | 1.00 | JAK3 (0.57) | JAK3JAK1JAK2TYK2TTK | |
| SCHEMBL28364413 | 0.91 | JAK3 (0.69) | JAK3JAK1JAK2TYK2TTK | |
| SCHEMBL21846881 | 0.91 | JAK3 (0.69) | JAK3JAK1JAK2TYK2TTK | |
| SCHEMBL29387512 | 0.90 | JAK3 (0.71) | JAK3JAK1JAK2TYK2TTK | |
| SCHEMBL21846871 | 0.90 | JAK3 (0.71) | JAK3JAK1JAK2TYK2TTK | |
| SCHEMBL28364432 | 0.90 | JAK3 (0.71) | JAK3JAK1JAK2TYK2TTK | |
| SCHEMBL29384938 | 0.90 | JAK3 (0.67) | JAK3JAK1JAK2TYK2TTK | |
| SCHEMBL21847361 | 0.90 | JAK3 (0.67) | JAK3JAK1JAK2TYK2TTK | |
| SCHEMBL21847331 | 0.90 | JAK3 (0.55) | JAK3JAK1JAK2TYK2TTK | |
| SCHEMBL29387383 | 0.90 | JAK3 (0.55) | JAK3JAK1JAK2TYK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11993603-B2 | Preparation for 6-amino-1H-pyrazolo[3,4-d]pyrimidine-based JAK kinase inhibitor and application thereof | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES & PEKING UNION MEDICAL COLLEGE (CN) | 2024-05-28 | — | — | US | disclosed |
| US-20220048914-A1 | PREPARATION FOR 6-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDINE-BASED JAK KINASE INHIBITOR AND APPLICATION THEREOF | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2022-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220048914-A1 | PREPARATION FOR 6-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDINE-BASED JAK KINASE INHIBITOR AND APPLICATION THEREOF | JAK1, JAK3, SSB | JAK3 2/4885JAK1 1/4885JAK2 5/4885 |
| US-11993603-B2 | Preparation for 6-amino-1H-pyrazolo[3,4-d]pyrimidine-based JAK kinase inhibitor and application thereof | JAK1, JAK3, SSB | JAK3 2/4885JAK1 1/4885JAK2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.