Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Vardenafil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A known ✓ | O76074 | 20/20 | 1.00 |
| ▸ | PDE1A | P54750 | 8/20 | 1.00 |
| ▸ | PDE1B | Q01064 | 8/20 | 1.00 |
| ▸ | PDE1C | Q14123 | 8/20 | 1.00 |
| ▸ | PDE6A | P16499 | 3/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 3/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 3/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 3/20 | 1.00 |
| ▸ | PDE2A | O00408 | 2/20 | 1.00 |
| ▸ | PDE6D | O43924 | 2/20 | 1.00 |
| ▸ | PDE9A | O76083 | 2/20 | 1.00 |
| ▸ | PDE6G | P18545 | 2/20 | 1.00 |
| ▸ | PDE4A | P27815 | 2/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | PDE6B | P35913 | 2/20 | 1.00 |
| ▸ | PDE6C | P51160 | 2/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 2/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vardenafil SCHEMBL5772 | 1.00 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE6A | |
| Vardenafil SCHEMBL5685 | 0.99 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE6A | |
| Vardenafil SCHEMBL973820 | 0.99 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE6A | |
| Vardenafil SCHEMBL5441 | 0.98 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL31347918 | 0.94 | PDE5A (0.90) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL24418486 | 0.94 | PDE5A (0.90) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL19197262 | 0.94 | PDE5A (0.88) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL13694 | 0.93 | PDE5A (0.87) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL5537 | 0.93 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL24430082 | 0.93 | PDE5A (0.88) | PDE5APDE1APDE1BPDE1CPDE6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166157-B | Double-acting mode soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof | 托帕杜制药公司 | 2024-08-27 | — | — | CN | disclosed |
| WO-2024158694-A1 | COMPOSITIONS AND METHODS FOR IMPROVING THE SOLUBILITY OF ERECTILE DYSFUNCTION THERAPEUTICS | Villya LLC (US) | 2024-08-02 | — | — | WO | disclosed |
| CN-111868037-B | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2023-10-13 | — | — | CN | disclosed |
| CN-115232134-B | Vardenafil analogue and synthesis method and application thereof | 广东西捷药业有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-115160321-B | Vardenafil analogue and synthesis method and application thereof | 广东西捷药业有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-110612285-B | Amide derivatives as Nav1.7 and Nav1.8 blockers | 拉夸里亚创药株式会社 | 2023-04-04 | — | — | CN | disclosed |
| CN-115232134-A | Vardenafil analogue and synthetic method and application thereof | 广东西捷药业有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-115160321-A | Vardenafil analogue and synthetic method and application thereof | 广东西捷药业有限公司 | 2022-10-11 | — | — | CN | disclosed |
| CN-114773350-A | Vardenafil analogue and synthetic method and application thereof | 广东西捷药业有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-114085225-A | Vardenafil analogue and synthetic method and application thereof | 广东西捷药业有限公司 | 2022-02-25 | — | — | CN | disclosed |