Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.59 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.59 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.34 |
| ▸ | GLS | O94925 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20721592 | 1.00 | PRMT5 (0.59) | PRMT5WDR77BRD4AURKARPS6KB1 | |
| SCHEMBL22663615 | 0.88 | PRMT5 (0.47) | PRMT5WDR77BRD4AURKARPS6KB1 | |
| SCHEMBL20721603 | 0.85 | PRMT5 (0.46) | PRMT5WDR77BRD4 | |
| SCHEMBL20721465 | 0.78 | PRMT5 (0.56) | PRMT5WDR77 | |
| SCHEMBL20721499 | 0.75 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL23897087 | 0.74 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL20721474 | 0.74 | PRMT5 (0.63) | PRMT5WDR77 | |
| SCHEMBL24430143 | 0.74 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| SCHEMBL20721543 | 0.74 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| SCHEMBL24199758 | 0.74 | PRMT5 (1.00) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3952874-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 | Prelude Therapeutics, Incorporated (US) | 2022-02-16 | — | — | EP | disclosed |