Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.84 |
| ▸ | FGFR2 | P21802 | 16/20 | 0.84 |
| ▸ | FGFR4 | P22455 | 16/20 | 0.84 |
| ▸ | FGFR3 | P22607 | 16/20 | 0.84 |
| ▸ | KDR | P35968 | 11/20 | 0.84 |
| ▸ | FLT1 | P17948 | 10/20 | 0.84 |
| ▸ | FLT4 | P35916 | 10/20 | 0.84 |
| ▸ | SRC | P12931 | 3/20 | 0.65 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | CSK | P41240 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | EGFR | P00533 | 4/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | PRKCG | P05129 | 1/20 | 0.59 |
| ▸ | PRKCB | P05771 | 1/20 | 0.59 |
| ▸ | PRKCA | P17252 | 1/20 | 0.59 |
| ▸ | PRKCH | P24723 | 1/20 | 0.59 |
| ▸ | PRKCI | P41743 | 1/20 | 0.59 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22532497 | 1.00 | FGFR1 (0.84) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL29388286 | 0.94 | FGFR1 (0.84) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL22532573 | 0.94 | FGFR1 (0.84) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL22532398 | 0.92 | FGFR1 (0.87) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL29391039 | 0.92 | FGFR1 (0.87) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL22531580 | 0.91 | FGFR1 (0.84) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL29388070 | 0.91 | FGFR1 (0.84) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL24490292 | 0.91 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL19601461 | 0.90 | FGFR1 (0.88) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL22532348 | 0.89 | FGFR1 (0.87) | FGFR1FGFR2FGFR4FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3952863-A1 | DEGRADERS OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2) | Dana-Farber Cancer Institute, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |