Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 19/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 15/20 | 0.53 |
| ▸ | METTL3 | Q86U44 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20721406 | 1.00 | PRMT5 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL20721471 | 0.91 | PRMT5 (0.61) | PRMT5WDR77METTL3 | |
| SCHEMBL29391293 | 0.91 | PRMT5 (0.61) | PRMT5WDR77METTL3 | |
| SCHEMBL29391668 | 0.91 | PRMT5 (0.61) | PRMT5WDR77METTL3 | |
| SCHEMBL20721538 | 0.91 | PRMT5 (0.61) | PRMT5WDR77METTL3 | |
| SCHEMBL20721481 | 0.90 | PRMT5 (0.55) | PRMT5WDR77METTL3 | |
| SCHEMBL29389132 | 0.90 | PRMT5 (0.55) | PRMT5WDR77METTL3 | |
| SCHEMBL20721529 | 0.87 | PRMT5 (0.51) | PRMT5WDR77METTL3 | |
| SCHEMBL29391408 | 0.87 | PRMT5 (0.51) | PRMT5WDR77METTL3 | |
| SCHEMBL20721605 | 0.85 | PRMT5 (0.54) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3952874-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 | Prelude Therapeutics, Incorporated (US) | 2022-02-16 | — | — | EP | disclosed |