Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19997549 | 0.85 | DYRK1A (0.47) | AAK1DYRK1AMAP4K4WNT3APDE3B | |
| SCHEMBL16593240 | 0.84 | DYRK1A (0.46) | AAK1DYRK1AMAP4K4WNT3APDE3B | |
| SCHEMBL16606159 | 0.84 | AAK1 (0.48) | AAK1DYRK1AMAP4K4WNT3APDE3B | |
| SCHEMBL24767561 | 0.84 | AAK1 (0.48) | AAK1DYRK1AMAP4K4WNT3APDE3B | |
| Bromide SCHEMBL16593406 | 0.83 | AAK1 (0.47) | AAK1DYRK1AMAP4K4WNT3APDE3B | |
| Bicarbonate SCHEMBL28852218 | 0.78 | AAK1 (0.44) | AAK1DYRK1AWNT3APSEN1PSEN2 | |
| SCHEMBL13036114 | 0.78 | DYRK1A (0.53) | AAK1DYRK1AMAP4K4WNT3APDE3B | |
| SCHEMBL14970119 | 0.75 | GRM2 (0.50) | AAK1DYRK1AMAP4K4MAPK13GCGR | |
| SCHEMBL22886739 | 0.75 | DYRK1A (0.50) | AAK1DYRK1AMAP4K4WNT3APDE3B | |
| SCHEMBL22001270 | 0.75 | MAP4K4 (0.50) | AAK1DYRK1AMAP4K4WNT3APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220041606-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | UNIV VANDERBILT (US) | 2022-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220041606-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | CHRM1, CHRM4, CHRM2 | AAK1 606/4885DYRK1A 690/4885RIPK3 1974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.