Stictic Acid

Stictic Acid

SCHEMBL29394416

COc1cc(C)c2c(c1C=O)Oc1c(c(C)c(O)c3c1C(O)OC3=O)OC2=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 1.00
MEN1 O00255 6/20 1.00
ALDH1A1 P00352 6/20 1.00
MAPT P10636 6/20 1.00
KMT2A Q03164 6/20 1.00
TDP1 Q9NUW8 6/20 1.00
HPGD P15428 4/20 1.00
CYP3A4 P08684 4/20 1.00
THRB P10828 3/20 1.00
RECQL P46063 3/20 1.00
PHPT1 Q9NRX4 2/20 1.00
POLB P06746 2/20 1.00
L3MBTL1 Q9Y468 2/20 1.00
CASP7 P55210 1/20 1.00
CASP6 P55212 1/20 1.00
ALOX12 P18054 2/20 0.77
CASP1 P29466 2/20 0.77
MED25 Q71SY5 1/20 0.77
SLCO1B3 Q9NPD5 1/20 0.77
SLCO1B1 Q9Y6L6 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Stictic Acid SCHEMBL13495711 1.00 KDM4E (1.00) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL15125069 0.89 MEN1 (0.80) KDM4EMEN1ALDH1A1MAPTKMT2A
Norstictic Acid SCHEMBL29369714 0.87 MAPT (1.00) KDM4EMEN1ALDH1A1MAPTKMT2A
Norstictic Acid SCHEMBL13287269 0.87 MAPT (1.00) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL15125097 0.84 KDM4E (0.71) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL17049615 0.78 MEN1 (0.68) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL6888417 0.77 MEN1 (0.62) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL15581643 0.76 KDM4E (0.66) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL15581642 0.76 MAPT (0.85) KDM4EMEN1ALDH1A1MAPTKMT2A
Slazinic Acid SCHEMBL3801772 0.76 MAPT (1.00) KDM4EMEN1ALDH1A1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250325548-A1 TUMOR SUPPRESSOR P73 TRANSCRIPTIONALLY REGULATES C-FLIP TO IMPEDE ITS PRIMING OF EXTRINSIC APOPTOSIS WHILE AN EXAMPLE SWITCHER COMPOUND CB-7587351 DEGRADES C-FLIP PROTEIN UNIV BROWN (US) 2025-10-23 US claimed
US-20250302863-A1 USE OF THBS1 INHIBITOR FOR OVERCOMING DRUG RESISTANCE IN CANCER KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2025-10-02 US claimed
WO-2023182846-A1 USE OF THBS1 INHIBITOR FOR OVERCOMING DRUG RESISTANCE IN CANCER 한국과학기술원 2023-09-28 WO claimed
US-20260132142-A1 EGFR INHIBITOR POLYMORPH FORMS KATMAI PHARMACEUTICALS INC (US) 2026-05-14 US disclosed
US-12545686-B2 Polymorphic forms of (s)-n-(3-bromo-2-fluorophenyl)-7-((4-methylpiperazin-1-yl)methyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine as EGFR inhibitors KATMAI PHARMACEUTICALS, INC. (US) 2026-02-10 US disclosed
US-20250368695-A1 Atranorin biosynthesis gene derived from lichens and uses thereof INDUSTRY ACADEMIC COOPERATION FOUNDATION OF SUNCHON NATIONAL UNIV (KR) 2025-12-04 US disclosed
WO-2025226956-A1 CATECHOL O-METHYLTRANSFERASE INHIBITORS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2025-10-30 WO disclosed
US-20250325548-A1 TUMOR SUPPRESSOR P73 TRANSCRIPTIONALLY REGULATES C-FLIP TO IMPEDE ITS PRIMING OF EXTRINSIC APOPTOSIS WHILE AN EXAMPLE SWITCHER COMPOUND CB-7587351 DEGRADES C-FLIP PROTEIN UNIV BROWN (US) 2025-10-23 US disclosed
US-20250302863-A1 USE OF THBS1 INHIBITOR FOR OVERCOMING DRUG RESISTANCE IN CANCER KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2025-10-02 US disclosed
US-20250145634-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2025-05-08 US disclosed
CN-115215808-B Compositions and methods for treating cancer 加利福尼亚大学董事会 2025-04-18 CN disclosed
CN-111565729-B Mp53 rescue compounds and methods of treating p53 disease 上海交通大学医学院附属瑞金医院 2023-01-24 CN disclosed
WO-2022260402-A1 ATRANORIN BIOSYNTHESIS GENE DERIVED FROM LICHEN AND USE THEREOF 순천대학교 산학협력단 2022-12-15 WO disclosed
CN-115215808-A Compositions and methods for treating cancer 加利福尼亚大学董事会 2022-10-21 CN disclosed
WO-2022219128-A1 IN VITRO TESTS ALLOWING TO IDENTIFY THE POTENTIAL FOR MDM2 INHIBITORS TO INDUCE THE SELECTION OF MUTATIONS IN PATIENTS SUFFERING FROM A MYELOPROLIFERATIVE NEOPLASM INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2022-10-20 WO disclosed
WO-2021232015-A9 PLATELET DERIVED EXTRACELLULAR VESICLES CELLPHIRE, INC. (US) 2022-09-15 WO disclosed
WO-2022174234-A2 BIOMARKERS FOR CANCER TREATMENT FOUNDATION MEDICINE, INC. (US) 2022-08-18 WO disclosed
US-11377451-B2 Compositions and methods for treating cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-07-05 US disclosed
WO-2022061201-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-03-24 WO disclosed
US-20220064177-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250145634-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER TP53, SLC2A1, EGFR KDM4E 3386/4885MEN1 3431/4885ALDH1A1 2784/4885
US-11377451-B2 Compositions and methods for treating cancer TP53, EGFR, SLC2A1 KDM4E 3091/4885MEN1 3595/4885ALDH1A1 2649/4885
US-20220064177-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER TP53, SLC2A1, EGFR KDM4E 3386/4885MEN1 3431/4885ALDH1A1 2784/4885
US-12545686-B2 Polymorphic forms of (s)-n-(3-bromo-2-fluorophenyl)-7-((4-methylpiperazin-1-yl)methyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine as EGFR inhibitors ERBB2, CYP1B1, EGFR KDM4E 2915/4885MEN1 3269/4885ALDH1A1 2721/4885
US-20250325548-A1 TUMOR SUPPRESSOR P73 TRANSCRIPTIONALLY REGULATES C-FLIP TO IMPEDE ITS PRIMING OF EXTRINSIC APOPTOSIS WHILE AN EXAMPLE SWITCHER COMPOUND CB-7587351 DEGRADES C-FLIP PROTEIN BCOR, CCAR2, CEBPZ KDM4E 967/4885MEN1 3174/4885ALDH1A1 3993/4885
US-20260132142-A1 EGFR INHIBITOR POLYMORPH FORMS EGFR, ERBB2, ERBB4 KDM4E 2558/4885MEN1 2346/4885ALDH1A1 3895/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.