SCHEMBL29395331

SCHEMBL29395331

O=[N+]([O-])c1ccc2c(I)n[nH]c2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.50
HPGD P15428 1/20 0.50
DAO P14920 1/20 0.50
CYP3A4 P08684 2/20 0.49
NOS1 P29475 2/20 0.49
LMNA P02545 2/20 0.49
ALOX15 P16050 1/20 0.49
PARP1 P09874 1/20 0.47
ALDH1A1 P00352 4/20 0.46
TDP1 Q9NUW8 1/20 0.46
NAMPT P43490 1/20 0.46
XDH P47989 1/20 0.46
POLB P06746 2/20 0.45
MAOB P27338 1/20 0.45
GRIA1 P42261 1/20 0.45
GRIA2 P42262 1/20 0.45
GRIA3 P42263 1/20 0.45
GRIA4 P48058 1/20 0.45
MAP2K7 O14733 1/20 0.44
NPC1 O15118 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1176140 1.00 MAPT (0.50) MAPTHPGDDAOCYP3A4NOS1
SCHEMBL29644044 0.87 MAPT (0.61) MAPTHPGDCYP3A4NOS1LMNA
SCHEMBL760614 0.87 MAPT (0.61) MAPTHPGDCYP3A4NOS1LMNA
Iodide SCHEMBL3532425 0.85 MAPT (0.60) MAPTHPGDCYP3A4NOS1LMNA
SCHEMBL921416 0.81 DAO (0.51) MAPTHPGDDAOCYP3A4NOS1
SCHEMBL2931498 0.81 JAK2 (0.51) MAPTHPGDDAOCYP3A4NOS1
SCHEMBL30833662 0.81 DAO (0.51) MAPTHPGDDAOCYP3A4NOS1
SCHEMBL29431208 0.81 JAK2 (0.51) MAPTHPGDDAOCYP3A4NOS1
SCHEMBL2595091 0.80 MAPT (0.50) MAPTHPGDDAOCYP3A4NOS1
SCHEMBL445096 0.80 MAPT (0.50) MAPTHPGDDAOCYP3A4NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3955914-A1 NOVEL COMPOUNDS AND METHODS OF USE TREATING FRUCTOSE-RELATED DISORDERS OR DISEASES Colorado Research Partners, LLC (US) 2022-02-23 EP disclosed