Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 7/20 | 0.48 |
| ▸ | PARP6 | Q2NL67 | 3/20 | 0.48 |
| ▸ | PARP3 | Q9Y6F1 | 3/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22912752 | 1.00 | PARP1 (0.51) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL22912749 | 0.85 | PARP1 (0.48) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL29394090 | 0.85 | PARP1 (0.48) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL30761017 | 0.83 | BRD4 (0.44) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL14014046 | 0.80 | GRIN2D (0.48) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL29396175 | 0.78 | GRIN2D (0.43) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL22912751 | 0.78 | GRIN2D (0.43) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL30634476 | 0.78 | GRIN2D (0.45) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL30634477 | 0.78 | PARP1 (0.50) | PARP1PARP2PARP6PARP3TNKS | |
| SCHEMBL30634480 | 0.77 | PARP1 (0.42) | PARP1PARP2PARP6PARP3TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116348115-B | Combination of antibody-drug conjugate and PARP1 selective inhibitor | ASTRAZENECA UK LTD. (GB) | 2026-05-26 | — | — | CN | disclosed |
| EP-4529952-A2 | PARP1 INHIBITORS | Astrazeneca AB (SE) | 2025-04-02 | — | — | EP | disclosed |
| EP-3999506-B1 | PARP1 INHIBITORS | ASTRAZENECA AB (SE) | 2025-01-15 | — | — | EP | disclosed |
| CN-114144413-B | PARP1 inhibitors | 阿斯利康(瑞典)有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-116348115-A | Combination of antibody-drug conjugate and PARP1 selective inhibitor | 阿斯利康(英国)有限公司 | 2023-06-27 | — | — | CN | disclosed |
| EP-3999506-A1 | PARP1 INHIBITORS | Astrazeneca AB (SE) | 2022-05-25 | — | — | EP | disclosed |
| CN-114144413-A | PARP1 inhibitors | 阿斯利康(瑞典)有限公司 | 2022-03-04 | — | — | CN | disclosed |