Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | PARP1 | P09874 | 8/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 8/20 | 0.47 |
| ▸ | PARP6 | Q2NL67 | 7/20 | 0.47 |
| ▸ | PARP3 | Q9Y6F1 | 6/20 | 0.47 |
| ▸ | TNKS | O95271 | 4/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22912736 | 1.00 | KDM4E (0.59) | KDM4EPARP1PARP2PARP6PARP3 | |
| SCHEMBL22912681 | 0.89 | EGFR (0.48) | KDM4EPARP1PARP2PARP6PARP3 | |
| SCHEMBL29394277 | 0.89 | EGFR (0.48) | KDM4EPARP1PARP2PARP6PARP3 | |
| SCHEMBL22912787 | 0.85 | KDM4E (0.59) | KDM4EPARP1PARP2PARP6PARP3 | |
| SCHEMBL29396632 | 0.85 | KDM4E (0.59) | KDM4EPARP1PARP2PARP6PARP3 | |
| SCHEMBL25318611 | 0.82 | KDM4E (0.62) | KDM4EPARP1PARP2PARP6PARP3 | |
| SCHEMBL30493540 | 0.82 | KDM4E (0.62) | KDM4EPARP1PARP2PARP6PARP3 | |
| SCHEMBL29394549 | 0.82 | PARP1 (0.47) | KDM4EPARP1PARP2PARP6PARP3 | |
| SCHEMBL26687928 | 0.82 | PARP1 (0.47) | KDM4EPARP1PARP2PARP6PARP3 | |
| SCHEMBL15303375 | 0.79 | KDM4E (0.62) | KDM4EPARP1PARP2PARP6PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116348115-B | Combination of antibody-drug conjugate and PARP1 selective inhibitor | ASTRAZENECA UK LTD. (GB) | 2026-05-26 | — | — | CN | disclosed |
| CN-114144413-B | PARP1 inhibitors | 阿斯利康(瑞典)有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-116348115-A | Combination of antibody-drug conjugate and PARP1 selective inhibitor | 阿斯利康(英国)有限公司 | 2023-06-27 | — | — | CN | disclosed |
| EP-3999506-A1 | PARP1 INHIBITORS | Astrazeneca AB (SE) | 2022-05-25 | — | — | EP | disclosed |
| CN-114144413-A | PARP1 inhibitors | 阿斯利康(瑞典)有限公司 | 2022-03-04 | — | — | CN | disclosed |