SCHEMBL2939871

SCHEMBL2939871

Cc1cnccc1CN1C(=O)N(c2ccc(SC(F)(F)F)cc2)C(=O)[C@H]1C

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 13/20 0.46
SMO Q99835 4/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2938928 1.00 IGF1R (0.46) IGF1RSMO
SCHEMBL2937739 1.00 IGF1R (0.46) IGF1RSMO
Trifluoroacetic Acid SCHEMBL3741568 0.94 IGF1R (0.43) IGF1RSMO
Trifluoroacetic Acid SCHEMBL3727713 0.94 IGF1R (0.43) IGF1RSMO
SCHEMBL2942050 0.90 IGF1R (0.44) IGF1R
SCHEMBL2942048 0.90 IGF1R (0.44) IGF1R
SCHEMBL2932219 0.90 IGF1R (0.46) IGF1RSMO
SCHEMBL2938688 0.90 IGF1R (0.46) IGF1RSMO
SCHEMBL2939338 0.90 IGF1R (0.46) IGF1RSMO
SCHEMBL2938044 0.89 IGF1R (0.47) IGF1RSMO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-B1 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA SA (FR) 2010-09-22 EP disclosed
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 WO disclosed