Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22659199 | 1.00 | BRAF (0.46) | BRAFKDM1AMAPK14MAPK13MAPT | |
| SCHEMBL24571432 | 0.93 | NTRK1 (0.42) | BRAFMAPTRAB9AGRIN2BNTRK1 | |
| SCHEMBL22659007 | 0.91 | BRAF (0.45) | BRAFKDM1AMAPK14MAPK13MAPT | |
| SCHEMBL22659082 | 0.88 | MAPK14 (0.53) | BRAFKDM1AMAPK14MAPK13MAPT | |
| SCHEMBL22659162 | 0.86 | BRAF (0.47) | BRAFKDM1AMAPK14GRIN2B | |
| SCHEMBL29405932 | 0.86 | BRAF (0.47) | BRAFKDM1AMAPK14GRIN2B | |
| SCHEMBL22659352 | 0.83 | NTRK1 (0.42) | BRAFMAPK14NTRK1 | |
| SCHEMBL22659123 | 0.83 | NTRK1 (0.49) | GRIN2BNTRK1 | |
| SCHEMBL22659859 | 0.83 | NTRK1 (0.42) | BRAFMAPTRAB9ANTRK1 | |
| SCHEMBL29405116 | 0.83 | NTRK1 (0.42) | BRAFMAPTRAB9ANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966208-A2 | COMPOUNDS AND METHODS FOR TREATING CANCER | Antidote IP Holdings, LLC (US) | 2022-03-16 | — | — | EP | disclosed |