Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 4/20 | 0.74 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.74 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | PPARA | Q07869 | 9/20 | 0.57 |
| ▸ | PPARG | P37231 | 3/20 | 0.57 |
| ▸ | PPARD | Q03181 | 3/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PYGL | P06737 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24735197 | 1.00 | PTGER4 (0.74) | PTGER4PTGER2NR1H4HPGDTP53 | |
| SCHEMBL24735202 | 0.90 | PTGER4 (0.61) | PTGER4PTGER2NR1H4HPGDTP53 | |
| SCHEMBL31518952 | 0.90 | PTGER4 (0.61) | PTGER4PTGER2NR1H4HPGDTP53 | |
| SCHEMBL29404563 | 0.89 | PTGER4 (0.60) | PTGER4PTGER2NR1H4HPGDTP53 | |
| SCHEMBL24735199 | 0.89 | PTGER4 (0.60) | PTGER4PTGER2NR1H4HPGDTP53 | |
| SCHEMBL23042429 | 0.86 | PPARA (0.64) | PTGER4PTGER2HPGDTP53GLA | |
| SCHEMBL26532908 | 0.86 | PTGER4 (0.56) | PTGER4PTGER2HPGDTP53GLA | |
| SCHEMBL4450973 | 0.85 | PTGER4 (1.00) | PTGER4PTGER2NR1H4HPGDPPARA | |
| SCHEMBL25336959 | 0.85 | PTGER4 (0.56) | PTGER4PTGER2NR1H4HPGDTP53 | |
| SCHEMBL11469323 | 0.85 | POLB (0.67) | PTGER4PTGER2NR1H4HPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4211117-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)-1-(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE | Loxo Oncology, Inc. (US) | 2023-07-19 | — | — | EP | claimed |
| CN-116323553-A | Processes and intermediates for preparing (S) -5-amino-3- (4- ((5-fluoro-2-methoxybenzamido) methyl) phenyl) -1- (1, 1-trifluoropropan-2-yl) -1H-pyrazole-4-carboxamide | 罗索肿瘤学公司 | 2023-06-23 | — | — | CN | claimed |
| WO-2022056100-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)-1-(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE | LOXO ONCOLOGY, INC. (US) | 2022-03-17 | — | — | WO | claimed |
| WO-2025083736-A1 | NOVEL PROCESS FOR THE PREPARATION OF PIRTOBRUTINIB AND ITS INTERMEDIATES THEREOF | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2025-04-24 | — | — | WO | disclosed |
| EP-4501327-A2 | SUBSTITUTED PYRROLOPYRIMIDINE AND PYRAZOLOPYRIMIDINE AS BRUTON S TYROSINEKINASE (BTK) DEGRADERS | Accutar Biotechnology Inc. (US) | 2025-02-05 | — | — | EP | disclosed |
| EP-4039688-B1 | SUBSTITUTED PYRROLOPYRIMIDINE AND PYRAZOLOPYRIMIDINE AS BRUTON'S TYROSINE KINASE (BTK) DEGRADERS | ACCUTAR BIOTECHNOLOGY INC (US) | 2024-10-09 | — | — | EP | disclosed |
| CN-118084722-A | Pitubultinib intermediate and preparation method thereof | 重庆兴泰濠制药有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-116655538-A | Preparation method of lymphoma treatment drug intermediate | 北京康立生医药技术开发有限公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-4211117-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)-1-(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE | Loxo Oncology, Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| CN-116323553-A | Processes and intermediates for preparing (S) -5-amino-3- (4- ((5-fluoro-2-methoxybenzamido) methyl) phenyl) -1- (1, 1-trifluoropropan-2-yl) -1H-pyrazole-4-carboxamide | 罗索肿瘤学公司 | 2023-06-23 | — | — | CN | disclosed |
| WO-2022169798-A2 | SUBSTITUTED PYRROLOPYRIMIDINE AND PYRAZOLOPYRIMIDINE AS BRUTON'S TYROSINE KINASE (BTK) DEGRADERS | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2022-08-11 | — | — | WO | disclosed |
| EP-4039688-A2 | SUBSTITUTED PYRROLOPYRIMIDINE AND PYRAZOLOPYRIMIDINE AS BRUTON'S TYROSINE KINASE (BTK) DEGRADERS | Accutar Biotechnology Inc. (US) | 2022-08-10 | — | — | EP | disclosed |
| WO-2022056100-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)-1-(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE | LOXO ONCOLOGY, INC. (US) | 2022-03-17 | — | — | WO | disclosed |