Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A5 | Q14940 | 6/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 5/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | SLC9A1 | P19634 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 2/20 | 1.00 |
| ▸ | THPO | P40225 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 2/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 1/20 | 1.00 |
| ▸ | HTR5A | P47898 | 1/20 | 1.00 |
| ▸ | PAX8 | Q06710 | 1/20 | 1.00 |
| ▸ | PLAU | P00749 | 10/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | BLM | P54132 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5-(N-Ethyl-N-Isopropyl)Amiloride SCHEMBL9852524 | 1.00 | SLC9A5 (1.00) | SLC9A5CYP1A2TSHRSLC9A1CYP2D6 | |
| SCHEMBL14504168 | 0.84 | CYP1A2 (0.77) | SLC9A5CYP1A2TSHRSLC9A1CYP2D6 | |
| SCHEMBL14513859 | 0.83 | SLC9A5 (0.77) | SLC9A5CYP1A2TSHRSLC9A1CYP2D6 | |
| 5-(N-Methyl-N-Isobutyl)Amiloride SCHEMBL9852472 | 0.80 | CYP1A2 (1.00) | SLC9A5CYP1A2TSHRSLC9A1CYP2D6 | |
| 5-(N-Methyl-N-Isobutyl)Amiloride SCHEMBL29404271 | 0.80 | CYP1A2 (1.00) | SLC9A5CYP1A2TSHRSLC9A1CYP2D6 | |
| SCHEMBL9852481 | 0.80 | CYP1A2 (1.00) | SLC9A5CYP1A2TSHRSLC9A1CYP2D6 | |
| SCHEMBL29406659 | 0.80 | CYP1A2 (1.00) | SLC9A5CYP1A2TSHRSLC9A1CYP2D6 | |
| SCHEMBL14513862 | 0.80 | CYP1A2 (0.69) | SLC9A5CYP1A2TSHRSLC9A1CYP2D6 | |
| 5-(N-Ethyl-N-Isopropyl)Amiloride SCHEMBL23663987 | 0.78 | CYP1A2 (0.64) | SLC9A5CYP1A2TSHRSLC9A1CYP2D6 | |
| 5-(N-Ethyl-N-Isopropyl)Amiloride SCHEMBL29375391 | 0.78 | CYP1A2 (0.64) | SLC9A5CYP1A2TSHRSLC9A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119633554-A | Smoke carbon dioxide capturing and regenerating system based on bi-component secondary amine | 中冶京诚工程技术有限公司 | 2025-03-18 | — | — | CN | disclosed |
| CN-119367546-A | Composition for enhancing glioma chemotherapeutic drug sensitivity and application thereof | 中国人民武装警察部队重庆市总队医院 | 2025-01-28 | — | — | CN | disclosed |
| CN-115005772-B | Plaque detection method and device based on OCT image and terminal equipment | 深圳市中科微光医疗器械技术有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-119265101-A | Method for repairing damaged islet beta cells, product and application | 南京师范大学 | 2025-01-07 | — | — | CN | disclosed |
| CN-116942669-B | Application of amiloride in preparation of medicine for preventing and treating mandarin rhabdovirus infection | 中国水产科学研究院珠江水产研究所 | 2024-02-23 | — | — | CN | disclosed |
| CN-116942669-A | Application of amiloride in preparation of medicine for preventing and treating mandarin rhabdovirus infection | 中国水产科学研究院珠江水产研究所 | 2023-10-27 | — | — | CN | disclosed |
| EP-4203930-A1 | NHE-1 INHIBITORS FOR THE TREATMENT OF CORONAVIRUS INFECTIONS | Fondation EspeRare (CH) | 2023-07-05 | — | — | EP | disclosed |
| CN-115005772-A | Plaque detection method and device based on OCT image and terminal equipment | 深圳市中科微光医疗器械技术有限公司 | 2022-09-06 | — | — | CN | disclosed |
| WO-2022125673-A1 | CELL-PENETRATING PEPTIDES AND PEPTIDE COMPLEXES AND METHODS OF USE | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2022-06-16 | — | — | WO | disclosed |
| WO-2022043343-A1 | NHE-1 INHIBITORS FOR THE TREATMENT OF CORONAVIRUS INFECTIONS | FONDATION ESPERARE (CH) | 2022-03-03 | — | — | WO | disclosed |
| EP-3960165-A1 | NHE-1 INHIBITORS FOR THE TREATMENT OF CORONAVIRUS INFECTIONS | Fondation EspeRare (CH) | 2022-03-02 | — | — | EP | disclosed |