SCHEMBL29404232

SCHEMBL29404232

C=C(C)c1nn(-c2c(F)cccc2Cl)c(=O)c2cc(F)c(-n3nc(COC(=O)C(F)(F)F)n(CC)c3=O)cc12

nearest known ligand 0.78

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 20/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22552494 1.00 DHODH (0.78) DHODH
SCHEMBL22552392 1.00 DHODH (0.78) DHODH
SCHEMBL29404141 1.00 DHODH (0.78) DHODH
SCHEMBL29401620 0.88 DHODH (1.00) DHODH
SCHEMBL22552202 0.88 DHODH (1.00) DHODH
SCHEMBL29401439 0.88 DHODH (1.00) DHODH
SCHEMBL22552173 0.88 DHODH (1.00) DHODH
SCHEMBL22552338 0.87 DHODH (0.78) DHODH
SCHEMBL22552475 0.87 DHODH (0.78) DHODH
SCHEMBL29401329 0.87 DHODH (0.78) DHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3956320-B1 DIHYDROOROTATE DEHYDROGENASE INHIBITORS JANSSEN BIOTECH INC (US) 2023-11-29 EP disclosed
EP-3956320-A1 DIHYDROOROTATE DEHYDROGENASE INHIBITORS Janssen Biotech, Inc. (US) 2022-02-23 EP disclosed