SCHEMBL29404584

SCHEMBL29404584

COc1ccc(F)cc1C(=O)NCc1ccc(B2OC(C)(C)C(C)(C)O2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
PPARA Q07869 7/20 0.48
PPARG P37231 3/20 0.48
PPARD Q03181 2/20 0.48
PTGER4 P35408 1/20 0.48
PTGER2 P43116 1/20 0.48
KMT2A Q03164 2/20 0.47
HPGD P15428 2/20 0.47
TP53 P04637 1/20 0.47
GLA P06280 1/20 0.47
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46
MAPK1 P28482 1/20 0.46
HTT P42858 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
EGFR P00533 1/20 0.45
BTK Q06187 1/20 0.45
POLB P06746 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21816957 1.00 CA1 (0.50) CA1CA2CA9PPARAPPARG
SCHEMBL30050255 0.93 CA1 (0.48) CA1CA2CA9PPARAPPARG
SCHEMBL21816962 0.92 CA1 (0.50) CA1CA2CA9KMT2AHPGD
SCHEMBL28754031 0.88 PPARA (0.47) PPARAPPARGPPARDPTGER4PTGER2
SCHEMBL29710948 0.88 PPARA (0.47) PPARAPPARGPPARDPTGER4PTGER2
SCHEMBL21817011 0.87 HPGD (0.64) CA1CA2CA9KMT2AHPGD
SCHEMBL28753991 0.87 PPARA (0.47) PPARAPPARGPPARDPTGER4PTGER2
SCHEMBL29711006 0.87 PPARA (0.47) PPARAPPARGPPARDPTGER4PTGER2
SCHEMBL18989291 0.87 PDE10A (0.47) PPARAPPARGPPARDKMT2AHPGD
SCHEMBL38652803 0.86 PPARA (0.46) PPARAPPARGPPARDPTGER4PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4039688-B1 SUBSTITUTED PYRROLOPYRIMIDINE AND PYRAZOLOPYRIMIDINE AS BRUTON'S TYROSINE KINASE (BTK) DEGRADERS ACCUTAR BIOTECHNOLOGY INC (US) 2024-10-09 EP disclosed
EP-4211117-A1 PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)-1-(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE Loxo Oncology, Inc. (US) 2023-07-19 EP disclosed
CN-116348453-A Heteroaromatic carboxamide compounds and uses thereof 烨辉医药科技(上海)有限公司 2023-06-27 CN disclosed
WO-2022228302-A1 HETEROAROMATIC CARBOXAMIDE COMPOUNDS AND ITS USE BIONOVA PHARMACEUTICALS (SHANGHAI) LIMITED (CN) 2022-11-03 WO disclosed
WO-2022169798-A2 SUBSTITUTED PYRROLOPYRIMIDINE AND PYRAZOLOPYRIMIDINE AS BRUTON'S TYROSINE KINASE (BTK) DEGRADERS ACCUTAR BIOTECHNOLOGY, INC. (US) 2022-08-11 WO disclosed
CN-114634512-A Compound as Bruton's tyrosine kinase inhibitor, preparation method and medical application thereof 江苏恒瑞医药股份有限公司 2022-06-17 CN disclosed
WO-2022056100-A1 PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)-1-(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE LOXO ONCOLOGY, INC. (US) 2022-03-17 WO disclosed