Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.64 |
| ▸ | SMO | Q99835 | 5/20 | 0.51 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.37 |
| ▸ | TAS2R8 | Q9NYW2 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2939667 | 1.00 | IGF1R (0.64) | IGF1RSMOTEAD1TAS2R8HSD11B1 | |
| SCHEMBL2939674 | 1.00 | IGF1R (0.64) | IGF1RSMOTEAD1TAS2R8HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL2942569 | 0.94 | IGF1R (0.58) | IGF1RSMOTAS2R8 | |
| Trifluoroacetic Acid SCHEMBL3727904 | 0.94 | IGF1R (0.58) | IGF1RSMOTAS2R8 | |
| Trifluoroacetic Acid SCHEMBL2940273 | 0.94 | IGF1R (0.58) | IGF1RSMOTAS2R8 | |
| SCHEMBL3002209 | 0.89 | IGF1R (0.52) | IGF1RSMOTEAD1HSD11B1HTT | |
| SCHEMBL3002202 | 0.89 | IGF1R (0.52) | IGF1RSMOTEAD1HSD11B1HTT | |
| SCHEMBL2934103 | 0.88 | IGF1R (0.64) | IGF1RSMOTEAD1TAS2R8 | |
| SCHEMBL2938125 | 0.86 | IGF1R (0.65) | IGF1RSMOTAS2R8 | |
| SCHEMBL2931866 | 0.86 | IGF1R (0.65) | IGF1RSMOTAS2R8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | claimed |
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | claimed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | claimed |
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |