Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.41 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1669232 | 1.00 | POLB (0.51) | POLBLMNASMN1; SMN2GBA2BIRC2 | |
| SCHEMBL27464999 | 1.00 | POLB (0.51) | POLBLMNASMN1; SMN2GBA2BIRC2 | |
| SCHEMBL18705787 | 0.91 | BIRC2 (0.42) | POLBLMNASMN1; SMN2GBA2BIRC2 | |
| SCHEMBL18706112 | 0.91 | BIRC2 (0.42) | POLBLMNASMN1; SMN2GBA2BIRC2 | |
| SCHEMBL18705785 | 0.91 | BIRC2 (0.42) | POLBLMNASMN1; SMN2GBA2BIRC2 | |
| SCHEMBL21296102 | 0.87 | POLB (0.48) | POLBLMNASMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL30578823 | 0.87 | POLB (0.48) | POLBLMNASMN1; SMN2GBA2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27854646 | 0.86 | POLB (0.47) | POLBLMNASMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL956554 | 0.85 | BIRC2 (0.45) | POLBLMNASMN1; SMN2BIRC2ALDH1A1 | |
| SCHEMBL317572 | 0.85 | BIRC2 (0.45) | POLBLMNASMN1; SMN2BIRC2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419527-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Artios Pharma Limited (GB) | 2024-08-28 | — | — | EP | disclosed |
| US-20230348471-A1 | BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD THEREFOR | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2023-11-02 | — | — | US | disclosed |
| WO-2023067355-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2023-04-27 | — | — | WO | disclosed |
| CN-114222743-A | Oxoaxamembered ring pyrimidine compounds, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2022-03-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348471-A1 | BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD THEREFOR | BTK, SYK, LCK | POLB 3052/4885LMNA 2975/4885SMN1; SMN2 3852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.