Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.55 |
| ▸ | TTK | P33981 | 5/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 3/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29409911 | 1.00 | LRRK2 (0.55) | LRRK2TTKBTKCLK1CLK2 | |
| SCHEMBL22658974 | 1.00 | LRRK2 (0.55) | LRRK2TTKBTKCLK1CLK2 | |
| SCHEMBL22658972 | 1.00 | LRRK2 (0.55) | LRRK2TTKBTKCLK1CLK2 | |
| SCHEMBL24556848 | 1.00 | LRRK2 (0.55) | LRRK2TTKBTKCLK1CLK2 | |
| SCHEMBL24556851 | 0.96 | LRRK2 (0.57) | LRRK2TTKBTKCLK1CLK2 | |
| SCHEMBL29409856 | 0.96 | LRRK2 (0.57) | LRRK2TTKBTKCLK1CLK2 | |
| SCHEMBL22658469 | 0.95 | LRRK2 (0.52) | LRRK2TTKBTKCLK1CLK2 | |
| SCHEMBL22658499 | 0.95 | LRRK2 (0.52) | LRRK2TTKBTKCLK1CLK2 | |
| SCHEMBL22658470 | 0.95 | LRRK2 (0.52) | LRRK2TTKBTKCLK1CLK2 | |
| SCHEMBL29409857 | 0.95 | LRRK2 (0.52) | LRRK2TTKBTKCLK1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3968990-A1 | PYRROLOPYRIMIDINE INHIBITORS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 | Dana-Farber Cancer Institute, Inc. (US) | 2022-03-23 | — | — | EP | disclosed |