Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 13/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26730569 | 0.79 | LRRK2 (0.38) | SMN1; SMN2ERN1ALDH1A1 | |
| SCHEMBL26629929 | 0.76 | ERN1 (0.38) | MALT1NR3C1ERN1 | |
| SCHEMBL17293141 | 0.75 | MALT1 (0.61) | MALT1 | |
| SCHEMBL26630077 | 0.74 | CCNT1 (0.49) | ERN1 | |
| SCHEMBL16244643 | 0.74 | BRD9 (0.50) | ALDH1A1 | |
| SCHEMBL23547410 | 0.74 | HAVCR2 (0.31) | — | |
| SCHEMBL26630222 | 0.74 | PDE4A (0.32) | MALT1 | |
| SCHEMBL26630017 | 0.74 | CDK2 (0.34) | SMN1; SMN2ERN1 | |
| SCHEMBL26730799 | 0.73 | BRD4 (0.43) | NR3C1ERN1ALDH1A1 | |
| SCHEMBL26629895 | 0.72 | SMN1; SMN2 (0.38) | SMN1; SMN2ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022061155-A1 | IMIDAZOPYRIDAZINE AND IMIDAZOPYRAZINE COMPOUNDS AS INHIBITORS OF CDK7 | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2022-03-24 | — | — | WO | disclosed |