Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 14/20 | 0.57 |
| ▸ | MAP2K2 | P36507 | 8/20 | 0.57 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 4/20 | 0.46 |
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.46 |
| ▸ | MAP3K9 | P80192 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | STK3 | Q13188 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1488199 | 1.00 | MAP2K1 (0.57) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL1488245 | 0.88 | MAP2K1 (0.53) | MAP2K1MAP2K2IDO1 | |
| SCHEMBL29413499 | 0.88 | MAP2K1 (0.53) | MAP2K1MAP2K2IDO1 | |
| SCHEMBL3426263 | 0.81 | MAP2K1 (0.46) | MAP2K1MAP2K2SRC | |
| SCHEMBL1342762 | 0.80 | IDO1 (0.60) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL1343634 | 0.80 | MAP2K1 (0.58) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL29413439 | 0.80 | MAP2K1 (0.43) | MAP2K1MAP2K2SRC | |
| SCHEMBL1343371 | 0.80 | MAP2K1 (0.43) | MAP2K1MAP2K2SRC | |
| SCHEMBL1344185 | 0.79 | MAP2K1 (0.57) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL24195834 | 0.77 | MAP2K1 (0.78) | MAP2K1MAP2K2IDO1AURKATNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053523-B | Azetidines as MEK inhibitors for the treatment of proliferative diseases | 埃克塞利希斯股份有限公司 | 2022-03-25 | — | — | CN | disclosed |